Pregnenolone (5 mg) is a sublingual bisect tablet formulated by Douglas Laboratories, containing highest purity pregnenolone and produced under strict Good Manufacturing Practices (GMP) standards.
Pregnenolone is a steroid synthesized from cholesterol in the mitochondria of the adrenal glands. It is also produced to a lesser extent in the brain, liver, skin, testes, and ovaries. Once synthesized, pregnenolone is released from the mitochondria into the cytosol, where it serves as a precursor to DHEA (dehydroepiandrosterone) and progesterone. DHEA in turn is a precursor to the androgens and estrogens through androstenedione as the intermediate compound. Progesterone is a precursor to cortisol, aldosterone, androstenedione, estrogen, and testosterone. Pregnenolone may also be secreted directly into the blood, where it circulates primarily as the sulfated form.
Pregnenolone is found in higher concentrations in the central nervous system compared to peripheral tissues, which may reflect its importance in supporting normal brain function. Douglas Laboratories notes that pregnenolone is important for the normal function of the brain, nervous tissue, liver, pancreas, reproductive tissues, pituitary, and skin. As with many hormones, pregnenolone production declines with age; it is estimated that pregnenolone production is approximately 60% less at age 75 than at age 35. Pregnenolone levels may also decline under conditions of physiological stress, including acute and chronic infections and trauma.
This product is formulated as a bisect tablet, identified as Formula #83057, and contains pregnenolone as 3-alpha-hydroxy-5-beta-pregnen-20-one. The tablet is scored to allow flexible half- or full-tablet dosing and is designed to dissolve in the mouth. It is intended as a nutritional supplement for adults wishing to supplement their diet with pregnenolone for hormone support, under the guidance of a qualified healthcare professional. Douglas Laboratories formulates this product using non-GMO ingredients and free from unnecessary additives and many common allergens.
| Supplement Facts | ||
|---|---|---|
| Serving Size 1 Bisected Tablet | ||
| Servings Per Container 100 | ||
| Amount Per Serving | %DV | |
| Pregnenolone (3-alpha-hydroxy-5-beta-pregnen-20-one) | 5 mg | * |
| * Daily Value not established. | ||
| Other Ingredients: Mannitol, cellulose, silica and vegetable stearate. | ||
| Warning: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS. DO NOT USE IF PREGNANT OR NURSING. Consult a physician or licensed qualified healthcare professional before using this product if you have or have a family history of breast cancer, uterine cancer, ovarian cancer, prostate cancer, prostate enlargement, heart disease, low HDL cholesterol ("good cholesterol"), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug. Do not exceed the recommended serving. Exceeding the recommended serving may cause serious adverse health effects. Possible side effects include changes in liver function, acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified healthcare professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms. KEEP OUT OF REACH OF CHILDREN. To report any adverse events call 1-800-332-1088. | ||
Pregnenolone — Serves as a precursor to DHEA and progesterone in the body, supporting normal hormone balance and normal function of the brain, nervous tissue, liver, pancreas, reproductive tissues, pituitary, and skin.
