What it is: InstaMed's Glutathione Sublingual Oral Strip delivers 80 mg of reduced L-glutathione (GSH) and 20 mg of N-Acetyl Cysteine (NAC) per strip via InstaRelease® buccal transmucosal dissolving technology — a needle-free, pre-dosed lemon-flavored format enabling direct mucosal GSH absorption alongside the cysteine precursor that supports endogenous glutathione biosynthesis. Third-party CoA-verified by Nutrastrips at 92.75 mg/strip GSH (NLT 80) and 21.08 mg/strip NAC (NLT 20), with full heavy metal and microbial conformance. 30 strips per box. GMP-certified and made in the USA.
How it works: Glutathione and NAC operate through two complementary and synergistic mechanisms of antioxidant and detoxification support. Reduced L-glutathione (GSH, 80 mg) is the body's primary intracellular antioxidant — a tripeptide (Glu-Cys-Gly) whose cysteine thiol group scavenges reactive oxygen and nitrogen species, regenerates oxidized vitamins C and E back to active antioxidant forms, and serves as the direct cofactor for glutathione-S-transferase-mediated Phase II hepatic detoxification of xenobiotics, heavy metals, and drug metabolites. Buccal transmucosal delivery via InstaRelease® bypasses the intestinal gamma-glutamyl transferase that degrades conventional oral GSH, enabling meaningful systemic absorption. NAC (20 mg) provides N-acetylated cysteine — the immediate precursor that replenishes intracellular cysteine stores and directly drives endogenous GSH synthesis via the gamma-glutamylcysteine synthetase pathway — extending the exogenous GSH delivery with sustained endogenous production support. NAC additionally provides direct mucolytic, antioxidant, and hepatoprotective activity independently of its GSH precursor role.
When to use it: Indicated for adults requiring direct GSH repletion and endogenous glutathione biosynthesis support across detoxification, antioxidant, hepatic, immune, neurological, and skin health protocols. Well-suited for mold and heavy metal detox programs, post-viral oxidative stress recovery, liver support, skin brightening and anti-aging protocols, and athletes requiring cellular antioxidant protection. One strip daily sublingually, or as directed by a healthcare practitioner. Consult a healthcare practitioner before use if pregnant, breastfeeding, or managing a medical condition.
Serving Size: 1 Strip
Servings Per Container: 30
Suggested Use: Place one strip on the tongue and allow it to dissolve, then swallow. Take 1 strip daily, or as directed by your healthcare practitioner.
| Ingredient | Amount Per Serving | % Daily Value |
|---|---|---|
| Calories | 0 | — |
| Calories from Fat | 0 | — |
| Total Fat | 0 | 0% |
| Glutathione | 80 mg | † |
| N-Acetyl Cysteine | 20 mg | † |
† Daily Value not established.
Other Ingredients: Pullulan, stevia, HPMC (hydroxypropyl methylcellulose), vegetable glycerin, lemon essential oil, malic acid, citric acid, sunflower lecithin, turmeric (color), xanthan gum, arabic gum.
Caution: If pregnant or nursing, consult your healthcare practitioner before use. Consult your healthcare practitioner before use if taking any medications or managing a medical condition. For adult use only. Keep out of reach of children. Store in a cool, dry place away from direct sunlight and excessive heat. Do not use if inner seal is broken or missing.
Dietary Designations: ✓ Gluten Free ✓ Soy Free ✓ Non-GMO ✓ Needle-Free ✓ Third-Party CoA Verified ✓ No Artificial Colors or Flavors ✓ GMP Certified
Key Ingredients:
Reduced L-Glutathione (GSH) — 80 mg Reduced glutathione is the biologically active, thiol-form tripeptide (Glu-Cys-Gly) that functions as the body's primary intracellular antioxidant and the essential cofactor for Phase II hepatic glutathione-S-transferase-mediated detoxification — delivered here at 80 mg per strip with third-party CoA verification of 92.75 mg/strip actual content and full conformance across heavy metals and microbials. GSH's cysteine thiol group scavenges reactive oxygen and nitrogen species, directly conjugates electrophilic toxins including heavy metals, drug metabolites, and environmental xenobiotics for biliary and urinary elimination, regenerates vitamins C and E from oxidized to active antioxidant forms, and supports NK cell and T-lymphocyte immune surveillance activity. InstaRelease® buccal strip delivery bypasses intestinal gamma-glutamyl transferase degradation — the enzyme that renders conventional oral GSH largely ineffective at increasing systemic glutathione levels — enabling direct transmucosal absorption for meaningful plasma GSH elevation.
N-Acetyl Cysteine (NAC) — 20 mg N-Acetyl Cysteine is the N-acetylated, membrane-permeable form of L-cysteine — the rate-limiting amino acid substrate for endogenous glutathione biosynthesis via gamma-glutamylcysteine synthetase — delivered at 20 mg per strip to complement and extend the exogenous GSH delivery through sustained intracellular cysteine replenishment and ongoing endogenous GSH production support. NAC independently provides direct antioxidant activity through its free thiol group, mucolytic activity through disulfide bond reduction in mucus glycoproteins, and hepatoprotective activity through acetaminophen toxicity rescue and hepatic GSH preservation — functions that operate in parallel to its GSH precursor role. The pairing of 80 mg exogenous GSH with 20 mg NAC in this formula addresses both the immediate plasma GSH deficit through direct buccal delivery and the sustained intracellular GSH production capacity through NAC-driven cysteine replenishment — a dual-mechanism approach that surpasses either ingredient delivered alone.
