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Pure Encapsulations

Glucosamine + Chondroitin With Manganese

Glucosamine + Chondroitin With Manganese

Supports joint comfort, cartilage structure, and connective tissue integrity by combining glucosamine HCl, chondroitin sulfate, and manganese ascorbate in a single vegetarian capsule.
  • Size:   120 capsules
  • Manufacturer:   Pure Encapsulations
  • SKU:   PGLUCHMN120
  • Stock status:   2
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Cartilage integrity depends on a continuous supply of structural building blocks — and this formula delivers two of the most clinically recognized: glucosamine HCl and chondroitin sulfate, paired with manganese ascorbate for broader connective tissue support.

Glucosamine HCl, sourced from crab and shrimp, promotes the synthesis of glycosaminoglycans, including chondroitin sulfate itself. Chondroitin sulfate — derived from bovine cartilage — is a primary structural component of articular cartilage and works to inhibit the activity of degradative enzymes that can compromise joint matrix integrity. Together, these two compounds may provide synergistic support for healthy hyaluronic acid content and synovial fluid.

Manganese ascorbate contributes on two fronts. The trace mineral manganese supports glycosaminoglycan and mucopolysaccharide production and promotes the antioxidant activity of superoxide dismutase. The ascorbate component serves as both an essential cofactor for collagen formation and an antioxidant in its own right — roles that are directly relevant to connective tissue maintenance.

The formula is certified gluten-free and non-GMO, encapsulated in a vegetarian capsule, and free from artificial additives. It is intended for adults 18 and older seeking to support joint comfort, cartilage structure, and connective tissue integrity. Consult a healthcare professional before use if pregnant, nursing, or taking blood-thinning medications.

Product name

Glucosamine + Chondroitin With Manganese

Short summary

This formula pairs two primary cartilage building blocks — glucosamine HCl and chondroitin sulfate — with manganese ascorbate to support healthy synovial fluid, articular cartilage integrity, and connective tissue maintenance. Manganese promotes superoxide dismutase activity and glycosaminoglycan production, while ascorbate serves as a cofactor for collagen formation. Certified gluten-free and non-GMO, the formula is designed for adults 18 and older.

What It Is

A vegetarian capsule formula providing 500 mg glucosamine HCl (from crab and shrimp), 400 mg chondroitin sulfate (from bovine cartilage), and 2 mg manganese as manganese ascorbate per serving. Designed to deliver complementary structural and antioxidant support for joint and connective tissue health.

How It Works

Glucosamine HCl promotes the synthesis of glycosaminoglycans, including chondroitin sulfate, which serves as a primary structural component of articular cartilage and helps inhibit degradative enzyme activity. Together, glucosamine and chondroitin may support healthy hyaluronic acid content and synovial fluid. Manganese supports glycosaminoglycan and mucopolysaccharide production and promotes the antioxidant activity of superoxide dismutase. Ascorbate contributes as both an antioxidant and an essential cofactor for collagen formation.

When To Use It

Appropriate for adults 18 and older seeking to support joint comfort, cartilage integrity, and connective tissue maintenance. An initial regimen taken in divided doses with meals for several weeks, followed by a maintenance regimen, is consistent with the manufacturer's suggested use. Consult a healthcare professional before use if pregnant, nursing, or taking other medications.

Suggested Use

Take in divided doses with meals as an initial regimen for several weeks, followed by a maintenance regimen taken in divided doses with meals, or use as directed by a healthcare professional.

Practitioner Note

This formula is certified gluten-free and non-GMO, and is free from artificial additives. Advise individuals that rare mild gastrointestinal symptoms such as abdominal bloating, diarrhea, or nausea may occur, and that use may be contraindicated with certain blood-thinning medications — consult a health professional before use in those cases. Contains shellfish (crab, shrimp).

Clinical Highlights

  • Glucosamine HCl: 500 mg per capsule, sourced from crab and shrimp, promotes glycosaminoglycan synthesis including chondroitin sulfate.
  • Bovine Chondroitin Sulfate: 400 mg per capsule, a primary structural component of articular cartilage that helps inhibit degradative enzyme activity and supports healthy synovial fluid.
  • Manganese Ascorbate: 2 mg elemental manganese (87% DV) per capsule; manganese supports glycosaminoglycan and mucopolysaccharide production and promotes superoxide dismutase antioxidant activity; ascorbate supports collagen formation.
  • Certifications: Certified Gluten-Free and Non-GMO; encapsulated in a vegetarian capsule (cellulose, water).
  • Allergen Disclosure: Contains shellfish (crab, shrimp).
Supplement Facts
Serving size 1 capsule
Servings per container 120
Amount Per Serving%DV
Manganese (as manganese ascorbate)2 mg87%
Glucosamine HCl (from crab, shrimp)500 mg*
Chondroitin sulfate (from bovine)400 mg*
* Daily value (DV) not established
Other ingredients: vegetarian capsule (cellulose, water), ascorbyl palmitate
Contains: shellfish (crab, shrimp)
Initial dose: 1 capsule, 3 times daily, with meals, for 2-3 weeks. Maintenance dose: 1 capsule, 2 times daily, with meals. Individual results may vary.