What it is:
Perna® Pro is an advanced, gluten-free joint and connective tissue support formula developed by DaVinci Labs, combining five clinically relevant ingredients — Perna canaliculus (green-lipped mussel), Glucosamine Sulfate Sodium, Methylsulfonylmethane (MSM), 5-LOXIN® Boswellia serrata extract, and Manganese — into a single, synergistic protocol. Designed for practitioner-directed use as either a standalone joint support formula or as a complementary addition to existing joint health protocols, Perna® Pro addresses multiple dimensions of musculoskeletal health including cartilage matrix synthesis, synovial lubrication, collagen production, and inflammatory pathway modulation. The formula is particularly distinguished by the inclusion of 5-LOXIN® — a patented, high-potency Boswellia serrata extract standardized to 30% AKBA — and the whole-food complexity of New Zealand green-lipped mussel, which provides a naturally occurring matrix of glycosaminoglycans, fatty acids, and structural joint nutrients not replicated by isolated compounds alone.
How it works:
Perna® Pro supports joint and connective tissue health through complementary structural, lubricating, anti-inflammatory, and mineral cofactor mechanisms. Perna canaliculus (green-lipped mussel), sourced from New Zealand, provides a naturally complex whole-food matrix rich in all classes of glycosaminoglycans — including chondroitin sulfates and hyaluronic acid — alongside omega-3 fatty acids, polypeptides, and chelated minerals that collectively support joint lubrication, synovial fluid viscosity, cartilage integrity, and range of motion. Glucosamine Sulfate Sodium serves as a direct biosynthetic building block for hyaluronic acid and chondroitin sulfate production within cartilage and connective tissue, supporting joint comfort and mobility through substrate-driven matrix repair and maintenance. MSM (methylsulfonylmethane) provides highly bioavailable organic sulfur — an essential structural component of collagen, proteoglycans, and the disulfide bonds that confer tensile strength to connective tissue — while also helping to support joint comfort and local circulation. 5-LOXIN® Boswellia serrata gum resin extract, standardized to 30% AKBA (3-acetyl-11-keto-beta-boswellic acid), selectively inhibits 5-lipoxygenase (5-LOX) — the enzyme responsible for leukotriene synthesis — providing targeted modulation of the inflammatory cascade implicated in joint tissue degradation, without the gastrointestinal concerns associated with NSAID-class agents. Manganese (as manganese citrate), a bioavailable chelated mineral form, serves as an essential enzymatic cofactor for the synthesis of collagen, proteoglycans, and glycosaminoglycans within articular cartilage and connective tissue, supporting the structural integrity and regenerative capacity of joint matrix components.
When to use it:
Perna® Pro is appropriate for practitioner-directed use in adult clients requiring comprehensive joint and connective tissue support, including those presenting with joint discomfort, reduced range of motion, cartilage wear, or connective tissue insufficiency associated with aging, physical activity, or inflammatory burden. It is well-suited for integration into musculoskeletal protocols for active clients, those in occupational roles involving repetitive joint loading, or clients seeking a multi-mechanistic alternative or adjunct to isolated glucosamine or chondroitin supplementation. The recommended dosing of two capsules twice daily supports sustained delivery of joint-protective nutrients throughout the day. As this formula contains crustacean shellfish (shrimp and crab), it is contraindicated in clients with shellfish allergies. Practitioner oversight is recommended for pregnant or nursing clients prior to use.
Serving Size: 1 Capsule
Servings Per Container: 90
Suggested Use: As a dietary supplement, take 1 capsule with a meal, 3 times daily, or as directed by your healthcare practitioner.
| Amount Per Serving | % Daily Value | |
|
Manganese (as Manganese Citrate)
|
2.5 mg | 109% |
|
Perna canaliculus (Green-Lipped Mussel)
|
750 mg | † |
|
Glucosamine Sulfate Sodium
|
450 mg | † |
| Methylsulfonylmethane (MSM) | 250 mg |
† |
|
5-LOXIN® Boswellia serrata (Gum Resin) Extract (yielding AKBA 15 mg)
|
50 mg |
† |
† Daily Value not established.
Other Ingredients: Microcrystalline cellulose, hypromellose (capsule), vegetarian leucine.
Caution: Contains crustacean shellfish (shrimp and crab). If pregnant or nursing, consult your healthcare practitioner before taking this product. Keep out of reach of children. Store in a cool, dry place. Color may vary due to natural ingredient variation.
✓ Gluten Free
Key Ingredients
Perna canaliculus (Green-Lipped Mussel) — 750 mg Perna canaliculus is a nutrient-dense edible shellfish species native to the pristine coastal waters of New Zealand, providing a naturally complex whole-food matrix that includes all classes of glycosaminoglycans — including chondroitin sulfates and hyaluronic acid — alongside omega-3 polyunsaturated fatty acids, polypeptides, naturally chelated minerals, and vitamins that occur in concentrations and structural forms not replicated by isolated synthetic compounds. The full-spectrum glycosaminoglycan content of green-lipped mussel directly mirrors the structural constituents of articular cartilage, synovial fluid, tendons, and ligaments, providing the biological substrates necessary for joint matrix maintenance, synovial lubrication, and connective tissue repair. At 750 mg per serving, Perna canaliculus serves as the foundational whole-food joint complex in this formula, supporting joint lubrication, flexibility, comfort, and range of motion through a multi-constituent mechanism unachievable by isolated glucosamine or chondroitin supplementation alone.
5-LOXIN® Boswellia serrata (Gum Resin) Extract — 50 mg (yielding 15 mg AKBA) 5-LOXIN® is a patented, highly concentrated Boswellia serrata gum resin extract standardized to 30% AKBA (3-acetyl-11-keto-beta-boswellic acid) — the most potent and pharmacologically active boswellic acid isomer — delivering a clinically meaningful AKBA dose at a fraction of the extract mass required by conventional boswellia extracts. AKBA selectively and potently inhibits 5-lipoxygenase (5-LOX), the enzyme that catalyzes the conversion of arachidonic acid into pro-inflammatory leukotrienes — particularly leukotriene B4 (LTB4) — a key mediator of joint tissue inflammation and matrix degradation. This targeted 5-LOX inhibition supports joint comfort, structural integrity, and healthy inflammatory balance within articular tissue, providing a mechanism of action complementary to the structural and substrate-driven support offered by the other ingredients in this formula.
Glucosamine Sulfate Sodium — 450 mg Glucosamine sulfate is the most clinically studied form of supplemental glucosamine, serving as a direct biosynthetic precursor and rate-limiting substrate for the endogenous synthesis of hyaluronic acid, chondroitin sulfate, and other glycosaminoglycans essential to cartilage matrix structure and synovial fluid viscosity. As a fast-acting nutritional building block for connective tissue, glucosamine sulfate supports the anabolic repair and maintenance of articular cartilage by providing the hexosamine backbone required by chondrocytes for proteoglycan and aggrecan synthesis. Supplemental glucosamine sulfate helps support joint comfort and mobility by addressing the decline in endogenous glucosamine biosynthesis associated with aging and chronic joint loading.
Methylsulfonylmethane (MSM) — 250 mg MSM is a naturally occurring organosulfur compound and one of the most bioavailable dietary sources of elemental sulfur — an essential structural component of collagen, keratin, and the disulfide bonds that confer mechanical strength and elasticity to connective tissue throughout the musculoskeletal system. Sulfur derived from MSM is directly incorporated into the collagen and proteoglycan matrix of cartilage, tendons, and ligaments, supporting the biosynthesis and cross-linking of structural connective tissue proteins necessary for joint integrity and resilience. Historically used to support joint comfort and local tissue circulation, MSM provides foundational sulfur substrate support that complements the glycosaminoglycan and inflammatory modulation mechanisms of the other ingredients in this formula.
Manganese (as Manganese Citrate) — 2.5 mg Manganese citrate is a well-absorbed organic mineral chelate that delivers manganese — an essential trace element and enzymatic cofactor — with superior bioavailability compared to inorganic manganese salts such as manganese sulfate or oxide. Manganese is a required cofactor for manganese superoxide dismutase (MnSOD), the primary mitochondrial antioxidant enzyme, and plays an indispensable role as a coactivator of the glycosyltransferases responsible for the biosynthesis of collagen, proteoglycans, and glycosaminoglycans within articular cartilage and connective tissue. Adequate manganese status is therefore a prerequisite for normal joint matrix synthesis and repair, making manganese citrate a clinically relevant mineral inclusion in any comprehensive joint and connective tissue support protocol.
