What it is: X)ES™ is a fourteen-ingredient botanical formula from Panaxea International supporting libido, adrenal-gonadal hormone balance, and sexual vitality in male and female adults. Key standardizations include Icariin 30% from Herba Epimedii and Osthole 10% from Fructus Cnidii monnieri. Contains Cornu Cervi (deer antler velvet) — not suitable for vegetarian protocols. Manufactured to Australian Pharmaceutical GMP standards for exclusive practitioner-directed use.
How it works: Icariin inhibits PDE5 to support nitric oxide-mediated vasodilation and arousal, while simultaneously exerting androgenic and phytoestrogenic receptor activity relevant to both male and female hormonal support. Osthole provides complementary PDE5 inhibitory and androgenic activity through a distinct coumarin mechanism. Curculigo and Morinda root drive adrenal-gonadal testosterone and DHEA production through HPG axis modulation. Rehmannia provides the yin-tonic and phytoestrogenic foundation supporting hormonal restoration and adrenal resilience. Deer antler velvet delivers growth factor precursors, IGF-1, and steroidogenic compounds supporting physical stamina and reproductive vitality. Cistanche, Eucommia, and Cornus add kidney-tonic, bone-supportive, and androgenic adaptogenic activity.
When to use it: Indicated for male and female adults with low libido, adrenal-gonadal depletion, reduced vitality, or hormonal imbalance. Two capsules twice daily; reduce to maintenance dosing once response is established. Not recommended in active inflammatory or febrile conditions, BPH, or adolescent populations. Not recommended during pregnancy.
Serving Size: 2 Capsules
Servings Per Container: 25
Suggested Use: As a dietary supplement, take 3 capsules twice daily (initial protocol), or 2 capsules twice daily for ongoing use, or as prescribed by your healthcare practitioner.
|
Ingredient |
Amount Per Serving |
% Daily Value |
|
Rehmannia Cured Root Tuber (Radix Rehmanniae Glutinosae / Shu Di) |
102.9 mg |
† |
|
Epimedium Above-Ground Parts (Herba Epimedii / Yin Yang Huo) Extract (contains standardized Icariin 30%) |
89 mg |
† |
|
Bai-zhu Atractylodes Rhizome (Atractylodis Macrocephalae / Bai Zhu) |
86.3 mg |
† |
|
Curculigo Rhizome (Curculiginis Orchioidis / Xian Mao) |
86.3 mg |
† |
|
Eucommia Stem Bark (Cortex Eucommiae Ulmoidis / Du Zhong) |
80.5 mg |
† |
|
Asian Ginseng Root (Ginseng / Ren Shen) |
79.8 mg |
† |
|
Cnidium Fruit (Fructus Cnidii Monnieri / She Chuang Zi) Extract (contains standardized Osthole 10%) |
72.9 mg |
† |
|
Lycium Fruit (Lycii / Gou Qi Zi) |
71.6 mg |
† |
|
Desert Broomrape Stem (Herba Cistanches Deserticolae / Rou Cong Rong) Extract (contains standardized β-Sitosterol 18%) |
67 mg |
† |
|
Morinda Root (Morindae Officinalis / Ba Ji Tian) Extract (contains standardized Morindin 4%) |
66.1 mg |
† |
|
Asiatic Dogwood Fruit without Seed (Corni Officinalis / Shan Zhu Yu) |
66.1 mg |
† |
|
Cornu Cervi (Lu Rong / Deer Antler Velvet) |
56.4 mg |
† |
|
Dong Quai Root (Angelicae Sinensis / Dang Gui) |
47.7 mg |
† |
|
Cassia Bark (Cinnamomi Cassiae / Rou Gui) |
27.4 mg |
† |
† Daily Value not established.
Other Ingredients: Vegetable cellulose (hypromellose), vegetable stearic acid, microcrystalline cellulose, vegetable magnesium stearate.
Does Not Contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts.
Caution: If pregnant, nursing, or taking medications, consult your healthcare practitioner before use. Do not use if you have known hypersensitivity to any of the ingredients. Do not use if tamper-evident seal is broken or missing. Keep out of reach of children. Store in a cool, dry place (<25°C) away from sunlight.
✓ Vegetarian ✓ Gluten Free ✓ Dairy Free ✓ Soy Free ✓ Egg Free ✓ Nut Free ✓ Australian Pharmaceutical GMP Manufactured
Key Ingredients
Herba Epimedii extract (standardized to Icariin 30%) — 44.5 mg Herba Epimedii is standardized to 30% Icariin — the prenylated flavonoid responsible for Epimedium's documented sexual function, androgenic, and bone-protective activity. Icariin inhibits PDE5 to support nitric oxide-mediated vasodilation in reproductive tissues, while simultaneously exerting androgen receptor-mediated testosterone-upregulating and phytoestrogenic receptor activity. It provides the formula's primary dual androgenic and vascular mechanism for both male and female sexual function support.
Radix Rehmanniae glutinosae — 51.45 mg Prepared Rehmannia root delivers catalpol, aucubin, and phytoestrogenic constituents with documented adrenocortical supportive, anti-inflammatory, and steroidal modulating activity. Catalpol modulates adrenal steroidogenic enzyme activity and supports bone marrow hematopoiesis, while phytoestrogenic constituents provide hormonal scaffolding for estradiol and progesterone balance in female clients. As the formula's highest-dose ingredient, it provides the yin-tonic and adrenal-supportive foundation upon which the formula's more tonifying androgenic botanicals operate.
Fructus Cnidii monnieri extract (standardized to Osthole 10%) — 36.45 mg Cnidium fruit is standardized to 10% Osthole — a coumarin with PDE5 inhibitory, androgenic, and bone-protective activity comparable to 17β-estradiol in supporting bone mineral density. Osthole reinforces Icariin's vascular and androgenic mechanisms through a structurally and pharmacologically distinct coumarin-based pathway. It is particularly relevant for peri- and post-menopausal female clients requiring combined sexual function and musculoskeletal support.
Rhizoma Curculiginis orchioidis — 43.15 mg Curculigo rhizome delivers curculigoside phenolic glycosides and cycloartan triterpene saponins with documented androgenic, bone-anabolic, and immunomodulatory activity. Curculigoside A stimulates osteoblast differentiation through Wnt/β-catenin signaling, while androgenic constituents support testosterone and DHEA production at the adrenal-gonadal level. It provides the formula's most directly androgenic kidney-yang tonic activity for both male and female clients with adrenal-gonadal insufficiency.
Radix Morindae officinalis extract (standardized to Morindin 4%) — 33.05 mg Morinda root is standardized to 4% Morindin — its primary iridoid glycoside marker — with documented androgenic, anti-osteoporotic, and adrenal-gonadal tonic activity in both male and female presentations. Its constituents support testosterone production and gonadotropin secretion through HPG axis modulation, and exert adaptogenic anti-fatigue effects at the mitochondrial level. It completes the formula's triple androgenic botanical combination with Epimedium and Curculigo.
