Th1 Support is a vegetarian capsule formula from Pure Encapsulations, part of the PureResponse™ Immune Protocol for healthy immune balance and function. It is designed to support healthy activation of Th1 cells and to promote innate immunity and cell-mediated immune defenses. Th1 responses are affected by stress, aging, and cytokine changes resulting from metabolic, hormonal, physiological, and environmental factors.
The formula contains a blend of five active components: berberine HCl, Chinese skullcap (Scutellaria baicalensis) root extract standardized to 30% baicalin, broccoli (Brassica oleracea italica) sprout concentrate from the whole plant standardized to contain 400 mcg sulforaphane, ginger (Zingiber officinale) root extract standardized to 5% gingerols, and zinc as zinc picolinate.
Clinical and preclinical studies cited by the manufacturer show that berberine positively influences immune biomarkers related to cell and tissue health. In vitro evidence suggests berberine supports maturation of T cells into Th1 cells and production of IL-12, an important Th1-promoting cytokine. Sulforaphane from broccoli promotes various aspects of immunological homeostasis that maintain the health of mucosal cells. Baicalin from skullcap offers support for healthy production of interferon gamma, promoting Th1-type immune responses, according to animal studies. Ginger, according to preclinical data, supports healthy cytokine balance including IL-6 and TNF-alpha production.
Cellular and animal models also suggest support for Th1-promoting interferon gamma and interleukin-2 production. The formula helps balance cytokine production to promote Th1 differentiation, and support for Th1 may be indicated for enhancement of natural defenses. Each serving of two capsules delivers the full active blend in a vegetarian capsule composed of cellulose and water, with no other excipients.
| Supplement Facts | ||
|---|---|---|
| Serving size 2 capsules | ||
| Servings per container 60 | ||
| Amount Per Serving | %DV | |
| Zinc (as zinc picolinate) | 10 mg | 91% |
| Berberine HCl | 500 mg | * |
| Chinese skullcap (Scutellaria baicalensis) extract (root) (standardized to contain 30% baicalin) | 300 mg | * |
| Broccoli (Brassica oleracea italica) sprout concentrate (whole plant) (standardized to contain 400 mcg sulforaphane) | 100 mg | * |
| Ginger (Zingiber officinale) extract (root) (standardized to contain 5% gingerols) | 120 mg | * |
| * Daily value (DV) not established | ||
| Other ingredients: vegetarian capsule (cellulose, water) | ||
Zinc (as zinc picolinate) — supports the normal mineral foundation for healthy immune cell activity and Th1 immune function.
Berberine HCl — supports maturation of T cells into Th1 cells and healthy production of IL-12, a Th1-promoting cytokine, and positively influences immune biomarkers related to cell and tissue health.
Chinese skullcap (Scutellaria baicalensis) extract (root), standardized to 30% baicalin — supports healthy production of interferon gamma, promoting Th1-type immune responses.
Broccoli (Brassica oleracea italica) sprout concentrate (whole plant), standardized to contain 400 mcg sulforaphane — promotes various aspects of immunological homeostasis that support the health of mucosal cells.
Ginger (Zingiber officinale) extract (root), standardized to 5% gingerols — supports healthy cytokine balance.
