Pure Encapsulations Synergy K is a vegetarian capsule combining vitamin K1, two forms of vitamin K2 (menaquinone-4 and menaquinone-7), and vitamin D3 (as cholecalciferol) in a single daily serving. It is formulated by Pure Encapsulations and is certified gluten-free, non-GMO, and hypoallergenic.
Vitamin K1 (phylloquinone) is the most common dietary form of vitamin K, found in plants and green vegetables. The vitamin K2 family, the menaquinones, are found in meats, eggs, some cheeses, and fermented foods. Synergy K provides two distinct menaquinone forms: menaquinone-4 (MK-4) and menaquinone-7 (MK-7). The manufacturer notes that vitamin K1 and MK-4 are primarily concentrated in the liver, while MK-7 concentrates in extra-hepatic tissues, including vascular tissues, and has a longer half-life. Vitamin D is provided as cholecalciferol (D3).
The combination of vitamin K and vitamin D in Synergy K is designed to support bone health and healthy arterial function. The manufacturer notes that vitamin D potentiates the activity of matrix Gla-protein (MGP) and that the combination of vitamin K and D provides synergistic support for blood vessel function and bone health.
Other ingredients are limited to hypoallergenic plant fiber (cellulose) and a vegetarian capsule (cellulose, water), with no unnecessary binders, fillers, or preservatives.
| Supplement Facts | ||
|---|---|---|
| Serving size 1 capsule | ||
| Servings per container 120 | ||
| Amount Per Serving | %DV | |
| Vitamin D (as cholecalciferol) (D3) | 25 mcg (1,000 IU) | 125% |
| Vitamin K1 | 500 mcg | 417% |
| Vitamin K2 (menaquinone-4) | 1,000 mcg | * |
| Vitamin K2 (menaquinone-7) | 45 mcg | * |
| * Daily value (DV) not established | ||
| Other ingredients: hypoallergenic plant fiber (cellulose), vegetarian capsule (cellulose, water) | ||
Vitamin D (as cholecalciferol, D3) — supports healthy calcium utilization and potentiates matrix Gla-protein (MGP) activity in concert with vitamin K for bone and vascular function.
Vitamin K1 — supports healthy bone formation and normal calcium metabolism, primarily concentrated in the liver.
Vitamin K2 (menaquinone-4) — supports healthy bone mineralization and calcium metabolism in the liver and extra-hepatic tissues.
Vitamin K2 (menaquinone-7) — concentrates in vascular and extra-hepatic tissues with a longer half-life; supports healthy calcium utilization in vascular tissues through its role in activating matrix Gla-protein (MGP).
