What it is: InstaMed's SLEEP Sublingual Oral Strip is a three-active peptide and amino acid sleep formula delivering DSIP (200 mcg), GABA (20 mg), and 5-HTP (10 mg) per strip alongside InstaRelease™ delivery complex (3 mg — Hydroxypropyl β-cyclodextrin, Penatratin, and Sunflower Lecithin) via buccal transmucosal dissolving strip technology. Formulated to support sleep onset, sleep architecture, delta-wave sleep induction, and GABAergic and serotonergic nervous system calming. Mint flavored, spirulina-colored, vegan, and free of all common allergens. 30 strips per box.
How it works: DSIP (Delta Sleep-Inducing Peptide, 200 mcg) is an endogenous neuropeptide originally isolated from rabbit cerebral venous blood during natural sleep, with documented capacity to modulate sleep-wake cycles through hypothalamic and limbic system DSIP receptor-mediated activity — promoting delta wave (slow-wave) sleep, reducing sleep onset latency, and normalizing disrupted circadian sleep architecture. Unlike sedative drugs, DSIP acts through endogenous neuromodulatory pathways without dependency or morning sedation risk. GABA (20 mg) provides direct GABAergic inhibitory nervous system support — reducing neuronal excitability, calming racing-mind presentations at bedtime, and complementing DSIP's hypothalamic sleep-promoting activity through a distinct receptor-mediated CNS-calming mechanism. 5-HTP (10 mg) provides serotonin precursor support — crossing the blood-brain barrier to support serotonin biosynthesis and the downstream melatonin production that regulates circadian sleep-wake cycle timing. The InstaRelease™ delivery complex (Hydroxypropyl β-cyclodextrin, Penatratin, and Sunflower Lecithin) facilitates transmucosal buccal absorption of all three actives — bypassing GI peptide degradation and first-pass hepatic metabolism for direct systemic delivery.
When to use it: Indicated for adults with sleep-onset difficulty, disrupted sleep architecture, anxiety-driven insomnia, or dysregulated circadian sleep-wake cycles. Place strip on top of tongue, press to roof of mouth, and allow to dissolve completely before swallowing. Take at bedtime nightly, or as directed by a healthcare practitioner. May cause drowsiness — do not drive or operate heavy machinery after use. Not recommended during pregnancy or breastfeeding. Use with caution alongside SSRIs, SNRIs, or other serotonergic medications due to 5-HTP content.
Serving Size: 1 Oral Strip
Servings Per Container: 30
Suggested Use: Place one oral strip on the top of the tongue and allow it to stick to the roof of the mouth. Let it dissolve completely, then swallow. Take at bedtime, or as directed by your healthcare practitioner.
| Ingredient | Amount Per Serving | % Daily Value |
|---|---|---|
| DSIP (Delta Sleep-Inducing Peptide) | 200 mcg | † |
| GABA | 20 mg | † |
| 5-HTP | 10 mg | † |
| InstaRelease™ (Hydroxypropyl β-cyclodextrin, Penatratin, Sunflower Lecithin) | 3 mg | † |
† Daily Value not established.
Other Ingredients: Pullulan, β-cyclodextrin, stevia, vegetable glycerin, organic mint flavor extract, xanthan gum, arabic gum, citric acid, sunflower lecithin, spirulina (color).
Caution: May cause drowsiness — do not drive or operate heavy machinery after use. Consult your healthcare practitioner before use if you are pregnant, nursing, taking medication — particularly SSRIs, SNRIs, or other serotonergic agents — or have a medical condition. For adult use only. Keep out of reach of children. Store in a cool, dry place away from direct sunlight and excessive heat. Do not use if package seal has been opened or tampered with.
✓ Vegan ✓ Gluten Free ✓ Dairy Free ✓ Soy Free ✓ Nut Free ✓ Fish Free ✓ Sugar Free ✓ Non-GMO ✓ No Artificial Colors or Flavors
Key Ingredients:
DSIP (Delta Sleep-Inducing Peptide) — 200 mcg DSIP is an endogenous neuropeptide originally isolated from the cerebral venous blood of rabbits during natural slow-wave sleep, with a well-documented neuromodulatory profile spanning sleep architecture regulation, hypothalamic-limbic system sleep signaling, and circadian rhythm normalization. DSIP promotes delta-wave (slow-wave) sleep through receptor-mediated hypothalamic modulation — reducing sleep onset latency and supporting deeper, more restorative sleep architecture without the dependency risk, morning sedation, or REM-suppressive effects associated with sedative-hypnotic medications. As the formula's primary active and most clinically specific sleep peptide, DSIP provides a neuroendocrine sleep-induction mechanism distinct from and complementary to the GABAergic and serotonergic mechanisms of GABA and 5-HTP within this triple-active buccal strip.
GABA (Gamma-Aminobutyric Acid) — 20 mg GABA is the brain's primary inhibitory neurotransmitter — delivered here via buccal transmucosal InstaRelease™ technology to maximize mucosal absorption and bypass the blood-brain barrier permeability limitations that reduce oral GABA bioavailability in conventional capsule formats. Buccal GABA delivery supports GABA-A and GABA-B receptor-mediated neuronal inhibition, reducing CNS excitability and promoting the neurological calm required for sleep onset — directly addressing racing-mind, hyperarousal, and anxiety-driven insomnia presentations that are not fully resolved by serotonergic agents alone. At 20 mg per strip, GABA provides the formula's primary CNS-calming and anxiolytic mechanism, complementing DSIP's hypothalamic sleep-architecture modulation and 5-HTP's serotonergic circadian support.
5-HTP (5-Hydroxytryptophan) — 10 mg 5-HTP is the immediate metabolic precursor to serotonin — crossing the blood-brain barrier directly to support serotonin biosynthesis, with downstream conversion to melatonin providing the circadian sleep-wake cycle timing signal that governs sleep onset and maintenance. At 10 mg per strip in buccal transmucosal format, 5-HTP provides the formula's serotonergic and melatonergic support — addressing the circadian rhythm disruption and serotonin deficit that underlie chronic insomnia, mood-associated sleep disturbance, and sleep-onset difficulty — completing the formula's triple-pathway sleep support matrix alongside DSIP's delta-wave induction and GABA's inhibitory nervous system calming.
