Deap [S]leap™

What it is: Deap [S]leap™ is a four-ingredient botanical sleep formula from Panaxea International, formulated by Master Herbalist Dr. Daniel Weber, combining whole-herb and isolated bioactive fractions from two clinically recognized sleep-supporting botanicals — Ziziphus jujuba var. spinosa and Polygala tenuifolia. The formula pairs Semen Ziziphi Spinosae whole herb (265 mg) with its isolated Jujuboside A 2% fraction (45 mg), and Radix Polygalae tenuifoliae whole herb (115 mg) with its isolated Senegenin 5% fraction (75 mg) — delivering both broad-spectrum whole-herb synergy and standardized isolate-level potency in a single capsule. Manufactured to Australian Pharmaceutical GMP standards for exclusive practitioner-directed use.

How it works: The dual whole-herb/isolate approach ensures that both the full botanical synergy of each herb and the peak activity of its primary bioactive are delivered simultaneously. Jujuboside A — the primary saponin glycoside of Ziziphus seed — modulates GABA-A receptor sensitivity and inhibits glutamate-mediated neuronal excitation, reducing arousal threshold and supporting sleep onset. Spinosin, co-delivered through the whole-herb fraction, provides complementary serotonergic modulation that supports sleep architecture and duration. Senegenin — the primary triterpenoid saponin of Polygala root — upregulates BDNF expression, modulates the HPA axis, and exerts sedative and anxiolytic activity through mechanisms distinct from Jujuboside A. The whole-herb Radix Polygalae fraction contributes acetylcholinesterase inhibitory activity and broader neuroprotective support alongside Senegenin's targeted sedative action.

When to use it: Indicated for adults with insomnia, disrupted sleep, sleep-onset difficulty, or anxiety-driven sleep disturbance. One capsule taken 30–60 minutes before bed. May cause drowsiness — advise clients not to operate heavy machinery after use. Use with caution alongside other sedative medications or supplements. Not recommended during pregnancy or breastfeeding without practitioner oversight.