What it is: PS Calm™ is a fourteen-ingredient botanical and phospholipid formula from Panaxea International supporting cortisol regulation, cognitive function, and sleep in adults under chronic stress. The formula anchors on 2000 mg of Phosphatidylserine derived from Phaseolus vulgaris — a non-soy source — alongside thirteen standardized adaptogenic and sedative botanicals. Manufactured to Australian Pharmaceutical GMP standards for exclusive practitioner-directed use.
How it works: Phosphatidylserine blunts HPA axis hyperreactivity, reducing stress-induced cortisol and ACTH output while supporting memory, attention, and processing speed. Ziziphus seed modulates GABA-A and serotonin receptors to promote sleep onset and reduce anxiety. Schisandra normalizes cortisol secretion and protects hepatic tissue under allostatic load. Polygala tenuifolia upregulates BDNF and inhibits acetylcholinesterase to address cognitive fog. Corydalis yanhusuo delivers tetrahydropalmatine — a dopamine receptor modulator with anxiolytic and mild antidepressant activity. Codonopsis and Astragalus restore the energy and immune reserves depleted by chronic stress. Cistanche and Poria cocos contribute neuroprotective, anti-fatigue, and GABAergic calming activity.
When to use it: Indicated for adults with chronic stress-related cognitive impairment, elevated cortisol, fatigue, mood disturbance, or dysregulated sleep. Well-suited for HPA axis rebalancing and post-burnout recovery protocols. Two to three capsules daily. Contraindicated in the first trimester of pregnancy and in clients with a history of miscarriage. Avoid during acute inflammatory illness.
Serving Size: 2 Capsules
Servings Per Container: 30
Suggested Use: As a dietary supplement, take 2–3 capsules daily, or as directed by your healthcare practitioner.
|
Ingredient |
Amount Per Serving |
% Daily Value |
|
Jujube (seed) Zizyphi Spinosae (Suan Zao Ren) |
97.6 mg |
† |
|
Dong Quai (root) Radix Angelicae Sinensis (Dang Gui) |
97.6 mg |
† |
|
Codonopsis (root) Codonopsis Pilosulae (Dang Shen) |
97.6 mg |
† |
|
Astragalus (root) Astragali Membranacei (Huang Qi) |
58.4 mg |
† |
|
Schisandra (fruit) Schisandrae Chinensis (Wu Wei Zi) |
58.4 mg |
† |
|
Oriental Arborvitae (seed) Semen Biotae Orientalis (Bai Zi Ren) |
58.4 mg |
† |
|
Desert Broomrape (stem) Herba Cistanches Deserticolae (Rou Cong Rong) |
58.4 mg |
† |
|
Polygala (root) Polygalae Tenuifoliae (Yuan Zhi) |
58.4 mg |
† |
|
Lycium (fruit) Fructus Lycii (Gou Qi Zi) |
58.4 mg |
† |
|
Poria (sclerotium) Poriae Cocos Paradicis (Fu Shen) |
58.4 mg |
† |
|
Corydalis yanhusuo (Yan Hu Su) |
39.2 mg |
† |
|
Chinese Arisemae (rhizome) Arisaematis (Tian Nan Xing) |
29.6 mg |
† |
|
Rhizoma Amemonis Altaicae (Jiu Jie Chang Pu) |
29.6 mg |
† |
|
Common Bean (Phaseolus vulgaris perforatum) (Cai Dou) (contains: standardized Phosphatidylserine) |
2000 mg |
† |
† Daily Value not established.
Other Ingredients: Vegetable cellulose (hypromellose), vegetable stearic acid, microcrystalline cellulose, vegetable magnesium stearate.
Caution: Not suitable for use during the acute phase of colds, flu, or other active inflammatory conditions. Some individuals may experience gastrointestinal upset or insomnia. Contraindicated during the first trimester of pregnancy and in clients with a personal or obstetric history of miscarriage. If taking medications or have a medical condition, consult your healthcare practitioner before use. Do not use if you have a known hypersensitivity to any of the ingredients. Do not use if the tamper-evident seal is broken or missing. Keep out of reach of children. Store in a cool, dry place away from sunlight.
✓ Vegetarian ✓ Gluten Free ✓ Dairy Free ✓ SoyFree ✓ Egg Free ✓ Nut Free
Key Ingredients
Common Bean (Phaseolus vulgaris) — standardized Phosphatidylserine — 2000 mg Phosphatidylserine in this formula is derived from Phaseolus vulgaris (Common bean) — a non-soy source delivering 2000 mg per serving, well above threshold doses studied in cortisol research. As a structural component of neuronal cell membranes, it blunts HPA axis hyperreactivity by attenuating stress-induced cortisol and ACTH hypersecretion. Multiple RCTs confirm its capacity to support memory, attention, and processing speed under chronic stress conditions.
Ziziphus jujuba var. spinosa (Jujube seed) — 97.6 mg Jujube seed is the formula's primary sedative nervine, with jujubosides, spinosin, and flavonoids modulating GABA-A receptor activity and serotonergic transmission. This dual mechanism promotes sleep onset, reduces anxiety, and calms cardiac restlessness — through pathways complementary to and distinct from Phosphatidylserine's HPA axis activity. It is the highest-dose botanical in the formula alongside Dong Quai and Codonopsis.
Schisandra chinensis (Schisandra fruit) — 58.4 mg Schisandra's dibenzocyclooctadiene lignans — schisandrin and schisandrin B — normalize stress-induced corticosteroid hypersecretion and upregulate hepatic antioxidant enzyme systems. This dual HPA axis-regulatory and hepatoprotective activity addresses both cortisol dysregulation and liver burden — two systems frequently compromised together under prolonged allostatic load. It supports mental performance and stress tolerance through a distinct adaptogenic mechanism from Codonopsis and Astragalus.
Corydalis yanhusuo (Corydalis rhizome) — 39.2 mg Corydalis delivers tetrahydropalmatine (THP) — a dopamine D1/D2 receptor modulator with documented anxiolytic, mild antidepressant, and opioid-independent analgesic activity. THP's mechanism is distinct from both benzodiazepine agonism and serotonin reuptake inhibition, offering a complementary mood-stabilizing pathway within this multi-botanical formula. It is particularly relevant for clients whose stress presentation includes pain-associated sleep fragmentation or emotional dysregulation.
Codonopsis pilosula (Codonopsis root) — 97.6 mg Codonopsis is a well-tolerated adaptogen with documented capacity to reduce physical and mental fatigue, modulate immune function, and protect gastric mucosa through its polysaccharide and triterpenoid constituents. It directly addresses the energy depletion, immune vulnerability, and digestive sensitivity that accompany burnout and chronic stress. At 97.6 mg — the formula's joint highest botanical dose — it anchors the formula's physical and cognitive vitality restoration activity.
