What it is: InstaMed's GHK-Cu Sublingual Oral Strip delivers 3 mg of high-purity GHK-Cu (copper tripeptide-1) per strip via proprietary InstaRelease® buccal transmucosal delivery technology — a needle-free, pre-dosed sublingual dissolving format enabling direct mucosal absorption without first-pass hepatic metabolism. GHK-Cu (Glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding tripeptide found endogenously in human plasma, saliva, and urine, with plasma concentrations declining significantly with age — from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60. Each strip is third-party CoA-verified at 99.8% purity by HPLC. Exclusively practitioner-directed.
How it works: GHK-Cu supports skin, hair, tissue repair, and systemic regenerative signaling through multiple converging mechanisms. It activates over 4,000 human genes involved in skin remodeling — upregulating collagen, elastin, proteoglycan, and glycosaminoglycan synthesis while simultaneously downregulating genes associated with inflammatory signaling and oxidative stress. GHK-Cu stimulates fibroblast proliferation and differentiation, promotes wound contraction, and supports dermal matrix remodeling through MMP (matrix metalloproteinase) regulation — accelerating both collagen breakdown of damaged tissue and new collagen deposition. It activates the ubiquitin-proteasome pathway to support cellular protein quality control and promotes anti-inflammatory gene expression through NF-κB pathway suppression. In hair follicle biology, GHK-Cu stimulates follicle stem cell activity and prolongs the anagen (active growth) phase — supporting healthy hair density and thickness. InstaRelease® buccal delivery enables transmucosal absorption bypassing GI peptide degradation.
When to use it: Indicated for adults in practitioner-directed protocols supporting skin health and anti-aging, hair density and growth, wound healing, tissue remodeling, and systemic anti-inflammatory and antioxidant resilience. One strip sublingually 5 days per week with 2 days off. Consult a healthcare practitioner before use if pregnant, breastfeeding, managing a medical condition, or taking medications. Not recommended in clients with known copper sensitivity or Wilson's disease.
Serving Size: 1 Strip
Servings Per Container: 20
Suggested Use: Place one strip on the tongue and allow it to dissolve, then swallow. Take 1 strip daily, 5 days per week with 2 days off, or as directed by your healthcare practitioner.
| Ingredient | Amount Per Serving | % Daily Value |
|---|---|---|
| Calories | 0 | — |
| Calories from Fat | 0 | — |
| Total Fat | 0 | 0% |
| GHK-Cu | 3 mg | † |
† Daily Value not established.
Other Ingredients: Pullulan, β-cyclodextrin, stevia, vegetable glycerin, natural tropical flavors, xanthan gum, arabic gum, citric acid, sunflower lecithin, turmeric (color).
Caution: Not recommended during pregnancy or breastfeeding. Not recommended in individuals with known copper sensitivity or Wilson's disease. Consult your healthcare practitioner before use if taking any medications or managing a medical condition. For adult use only. Keep out of reach of children. Store in a cool, dry place away from direct sunlight and excessive heat. Do not use if inner seal is broken or missing.
✓ Gluten Free ✓ Soy Free ✓ Non-GMO ✓ Needle-Free ✓ Third-Party CoA Verified ✓ No Artificial Colors or Flavors
Key Ingredients:
GHK-Cu (Glycyl-L-histidyl-L-lysine copper complex) — 3 mg GHK-Cu is a naturally occurring copper-binding tripeptide found endogenously in human plasma, saliva, and urine — with plasma concentrations peaking at approximately 200 ng/mL at age 20 and declining to roughly 80 ng/mL by age 60, positioning GHK-Cu supplementation as a targeted aging-related peptide repletion strategy — delivered here at 3 mg per strip with third-party CoA verification of 99.8% purity by HPLC and full conformance across heavy metals and microbial specifications. GHK-Cu's regenerative mechanisms operate at the genomic level — published research by Loren Pickart and colleagues identified over 4,000 human genes modulated by GHK-Cu, including upregulation of collagen I, collagen III, elastin, decorin, and glycosaminoglycan synthesis genes for dermal matrix restoration, alongside downregulation of inflammatory cytokine and oxidative stress genes through NF-κB pathway suppression. At the cellular level, GHK-Cu stimulates fibroblast proliferation and migration, activates matrix metalloproteinase-regulated tissue remodeling to remove damaged protein structures and promote new ECM deposition, activates hair follicle stem cells to extend the anagen growth phase and support hair density, and promotes ubiquitin-proteasome pathway activity for cellular protein quality control — collectively supporting skin remodeling, wound healing, hair follicle biology, and systemic tissue regeneration in a single tripeptide complex delivered via InstaRelease® buccal transmucosal absorption for needle-free systemic bioavailability.
InstaRelease® Delivery Technology (Buccal Transmucosal Strip Matrix) — per strip The InstaRelease® oral dissolving strip matrix is InstaMed's proprietary buccal transmucosal delivery platform, engineered from pullulan film-forming base, β-cyclodextrin inclusion complex technology for peptide solubilization and mucosal contact optimization, and a turmeric-colored tropical-flavored sensory matrix for practitioner and client compliance. The strip dissolves sublingually within seconds — delivering GHK-Cu directly across the buccal and sublingual mucosa into systemic circulation, bypassing the hepatic first-pass metabolism and GI proteolytic degradation that significantly limit conventional oral peptide bioavailability. This needle-free, pre-dosed, travel-compatible format brings clinical-grade copper peptide delivery into accessible daily use — supporting consistent peptide plasma exposure across the 5-days-on, 2-days-off cycle protocol without injection, without water, and without the compliance barriers of injectable peptide programs.
