What it is: Vitamin K2 + Resveratrol is a targeted, two-ingredient bone, cardiovascular, and neurological support formula developed by DaVinci Labs, combining 500 mcg of Vitamin K2 (as Menaquinone-7/MK-7) with 100 mg of Japanese Knotweed (Polygonum cuspidatum) root extract standardized to yield 50 mg of trans-resveratrol per capsule. This novel dual-ingredient combination is designed to address bone mineral density, vascular health, and free radical protection through complementary and synergistic mechanisms — with Vitamin K2 providing carboxylation-dependent calcium direction into bone matrix and arterial calcification inhibition, and trans-Resveratrol providing phytoestrogen-mediated bone mineralization support, polyphenol antioxidant cardiovascular protection, and sirtuin pathway-mediated cellular health activity. Designed for practitioner-directed use, Vitamin K2 + Resveratrol is particularly well-suited for women's bone health protocols during and after menopause, and for comprehensive cardiovascular antioxidant support programs.
How it works: Vitamin K2 + Resveratrol supports bone, cardiovascular, and neurological health through two distinct and complementary mechanisms that converge on calcium metabolism, vascular protection, and antioxidant defense. Vitamin K2 (as Menaquinone-7/MK-7) functions as the essential enzyme cofactor for gamma-carboxylase, which carboxylates two critical calcium-regulating proteins: osteocalcin, which requires carboxylation to develop the glutamate-derived structural binding domains necessary for calcium anchoring within hydroxyapatite bone matrix; and matrix Gla-protein (MGP), the most potent physiological inhibitor of arterial and soft tissue calcification, which requires K2-dependent carboxylation to actively redirect calcium away from vascular walls. Additionally, Vitamin K2 exerts regulatory influence over Vitamins A and D with respect to osteoclast and osteoblast activity, contributing to the hormonal coordination of bone remodeling. Trans-Resveratrol (50 mg per capsule from Polygonum cuspidatum root) — the biologically active isomer of resveratrol — supports bone health through its established phytoestrogen activity, binding to estrogen receptors (particularly ERβ) in osteoblasts to promote bone formation and mineralization processes, a mechanism of particular clinical relevance for women experiencing declining estrogen levels during and after menopause where estrogen-dependent bone loss accelerates. Resveratrol's polyphenolic antioxidant activity supports cardiovascular health through inhibition of LDL oxidation, reduction of platelet aggregation tendency, support of blood vessel pliability and flexibility, and activation of SIRT1 — the NAD-dependent deacetylase enzyme linked to cardiovascular protection, mitochondrial biogenesis, and neuronal health through its role in cellular stress response and inflammation modulation.
When to use it: Vitamin K2 + Resveratrol is appropriate for practitioner-directed use in adult clients requiring targeted bone mineral density support, vascular calcification protection, and cardiovascular antioxidant defense — with particular clinical relevance for perimenopausal and postmenopausal women where both estrogen-mediated bone loss and cardiovascular risk are elevated. It is well-suited for integration into bone health protocols as a companion to Vitamin D3 supplementation (providing the K2 cofactor essential for safe and effective high-dose D3 supplementation), into women's health and menopause support programs leveraging resveratrol's phytoestrogen bone-mineralization activity, and into cardiovascular antioxidant protocols where LDL oxidation protection and vascular pliability support are clinical objectives. One capsule daily with food supports consistent MK-7 carboxylation activity and trans-resveratrol bioavailability.
Serving Size: 1 Capsule
Servings Per Container: 60
Suggested Use: As a dietary supplement, take 1 capsule daily, or as directed by your healthcare practitioner.
| Amount Per Serving | % Daily Value | |
| Japanese Knotweed (Polygonum cuspidatum) Root Extract (yielding trans-Resveratrol 50 mg) | 100 mg | * |
| Vitamin K2 (as Menaquinone-7) | 500 mcg | * |
* Daily Value not established.
Other Ingredients: Microcrystalline cellulose, vegetable cellulose, vegetarian leucine.
Caution: If pregnant or nursing, consult your healthcare practitioner before taking this product. Discontinue use 2 weeks prior to surgery. Keep out of reach of children. Store in a cool, dry place. Color may vary due to natural ingredient variation.
✓ Vegetarian ✓ Gluten Free ✓ Soy Free
Key Ingredients
Vitamin K2 (as Menaquinone-7) — 500 mcg Menaquinone-7 (MK-7) is the long-chain, most bioavailable and longest-acting form of vitamin K2, characterized by a serum half-life of approximately 72 hours that enables sustained gamma-carboxylase cofactor activity throughout peripheral tissues including bone and vasculature on a once-daily dosing schedule. As the essential coenzyme for gamma-carboxylation, MK-7 activates osteocalcin — providing the glutamate-derived calcium-binding structural domains that anchor calcium ions within hydroxyapatite bone matrix — and carboxylates matrix Gla-protein (MGP), the most potent physiological inhibitor of arterial and soft tissue calcification, which in its activated, carboxylated form actively sequesters and redirects free calcium away from vascular walls to prevent arterial stiffening. Vitamin K2 additionally exerts regulatory influence over Vitamins A and D with respect to osteoclast and osteoblast differentiation and activity, contributing to the coordinated hormonal regulation of bone remodeling and providing the critical safety cofactor that ensures calcium mobilized by Vitamin D3 is deposited appropriately in bone rather than in soft tissue or vasculature.
Trans-Resveratrol (from Japanese Knotweed Polygonum cuspidatum Root Extract) — 50 mg Trans-resveratrol is the biologically active isomeric form of resveratrol — a stilbene polyphenol phytoalexin produced by grapevines, Japanese Knotweed, and other plants in response to environmental stressors — delivered here from Polygonum cuspidatum root extract standardized to yield 50 mg of the pure trans-isomer per capsule, providing a clinically relevant and bioavailable resveratrol dose. As a phytoestrogen, trans-resveratrol binds selectively to estrogen receptor beta (ERβ) in osteoblasts, supporting bone formation signaling, osteoblast proliferation, and the mineralization processes that are diminished in estrogen-deficient states — making it a particularly relevant bone support ingredient for perimenopausal and postmenopausal women experiencing accelerated estrogen-dependent bone loss. Trans-resveratrol's cardiovascular protection mechanisms include inhibition of LDL oxidation through its polyphenolic antioxidant activity, support for blood vessel pliability and platelet aggregation balance, and activation of SIRT1 — the NAD-dependent deacetylase central to cellular stress adaptation, mitochondrial biogenesis, and the suppression of NF-κB-driven inflammatory gene expression in vascular endothelial and neuronal tissue.
