What it is: Vitamin K2 Plus is a targeted, three-ingredient bone health and calcium utilization formula developed by DaVinci Labs, combining Vitamin K2 (as Menaquinone-7/MK-7), Vitamin D3 (as cholecalciferol), and Inulin — a prebiotic fructan fiber — within a single gluten-free, soy-free capsule. Unlike standard Vitamin K2 or D3 formulas, Vitamin K2 Plus uniquely incorporates Inulin as a functional third ingredient, providing prebiotic fiber-mediated enhancement of intestinal calcium absorption from dietary sources alongside the direct calcium-directing and bone-building mechanisms of K2 and D3. This three-way synergistic approach addresses calcium metabolism comprehensively — from intestinal absorption through dietary calcium uptake, to systemic calcium direction into bone matrix and away from soft tissue — making it a clinically distinctive bone support formula for practitioner-directed protocols.
How it works: Vitamin K2 Plus supports bone health and calcium metabolism through three complementary and sequentially integrated mechanisms. Vitamin D3 (as cholecalciferol) activates intestinal calcium transport proteins through vitamin D receptor (VDR)-mediated gene expression, significantly enhancing the fractional absorption of dietary calcium in the small intestine and promoting renal calcium reabsorption — increasing the systemic availability of calcium for skeletal mineralization. Vitamin K2 (as Menaquinone-7/MK-7), the long-chain, most bioavailable and longest-acting form of vitamin K2, serves as an essential enzyme cofactor for the gamma-carboxylation of two critical calcium-regulating proteins: osteocalcin, which requires carboxylation to develop the structural "claws" necessary to bind calcium into hydroxyapatite bone matrix; and matrix Gla-protein (MGP), the primary inhibitor of vascular and soft tissue calcification, which requires carboxylation by K2 to actively redirect calcium away from arterial walls and into bone. When vitamin K2 is insufficient, both osteocalcin and MGP remain undercarboxylated — leaving calcium unable to be properly integrated into bone and free to drift into soft tissue and vasculature. Inulin, a naturally occurring prebiotic fructan fiber derived from chicory root, supports calcium absorption through a complementary intestinal mechanism: fermentation by colonic microflora produces short-chain fatty acids (SCFAs) that lower luminal pH, increasing the solubility and passive absorption of calcium across the colonic epithelium — a calcium absorption pathway that operates independently from the active, VDR-mediated mechanism supported by Vitamin D3. Together, these three ingredients address calcium metabolism across the full physiological arc from intestinal uptake to skeletal integration.
When to use it: Vitamin K2 Plus is appropriate for practitioner-directed use in adult clients requiring targeted nutritional support for bone health, calcium utilization, and vascular protection from soft tissue calcification. It is particularly well-suited for integration into bone health and osteopenia protocols as a lower-dose, maintenance-oriented complement to higher-potency ADK formulas, for clients requiring vitamin K2 and D3 support alongside prebiotic fiber for gut-mediated calcium absorption enhancement, or for those on long-term antibiotic therapy where vitamin K status may be compromised through disruption of intestinal microbiota. Flexible dosing of one capsule once to twice daily supports individualized titration. This formula is contraindicated in clients taking anticoagulant or antiplatelet medications including Warfarin/Coumadin without appropriate clinical supervision.
Serving Size: 1 Capsule
Servings Per Container: 60
Suggested Use: As a dietary supplement, take 1 capsule once or twice daily, or as directed by your healthcare practitioner.
| Amount Per Serving | % Daily Value | |
| Vitamin D3 (as Cholecalciferol) | 5 mcg (200 IU) | 25% |
| Inulin | 750 mg | * |
| Vitamin K2 (as Menaquinone-7) | 50 mcg | * |
* Daily Value not established. Percent Daily Values are based on a 2,000-calorie diet.
Other Ingredients: Hypromellose (capsule), vegetarian leucine.
Caution: Do not take this product if you are taking anticoagulant/antiplatelet drugs such as Warfarin/Coumadin. If pregnant or nursing, consult your healthcare practitioner before taking this product. Keep out of reach of children. Store in a cool, dry place. Color may vary due to natural ingredient variation.
✓ Gluten Free ✓ Soy Free
Key Ingredients
Vitamin K2 (as Menaquinone-7) — 50 mcg Menaquinone-7 (MK-7) is the long-chain, most bioavailable and longest-acting form of vitamin K2, characterized by a serum half-life of approximately 72 hours — significantly exceeding that of shorter-chain menaquinones and vitamin K1 — enabling sustained carboxylation enzyme cofactor activity in peripheral tissues including bone and vasculature throughout a once-daily dosing interval. MK-7 activates the gamma-carboxylation of osteocalcin — the bone matrix protein that requires carboxylation to develop the glutamate-derived structural binding sites necessary to anchor calcium ions into hydroxyapatite — and matrix Gla-protein (MGP), the principal inhibitor of vascular and soft tissue calcification, which requires K2-dependent carboxylation to actively redirect free calcium away from arterial walls and into the skeletal matrix. Inadequate vitamin K2 status — commonly arising from poor dietary intake, prolonged antibiotic use, or fat malabsorption — results in undercarboxylated osteocalcin and MGP, leaving calcium unable to integrate properly into bone and free to accumulate in vascular and soft tissue, establishing MK-7 as an essential cofactor in any clinically comprehensive bone and cardiovascular calcium management protocol.
Vitamin D3 (as Cholecalciferol) — 5 mcg (200 IU) Cholecalciferol is the preferred physiologically active dietary form of vitamin D, identical to the form synthesized endogenously in human skin upon UVB exposure, and the most effective dietary form at raising and sustaining serum 25(OH)D concentrations. Following hepatic and renal hydroxylation to its active hormone form calcitriol, cholecalciferol binds to the nuclear vitamin D receptor (VDR) to upregulate the expression of intestinal calcium transport proteins — including calbindin-D9k and TRPV6 — significantly enhancing active calcium absorption in the small intestine and providing the systemic calcium availability necessary for osteoblast-mediated bone mineralization. At 200 IU per capsule, this formula provides a supportive maintenance dose of Vitamin D3 designed to complement the intestinal calcium absorption enhancement provided by Inulin and the downstream calcium-directing activity of Vitamin K2, functioning as the first stage of the formula's three-step calcium metabolism support system.
Inulin — 750 mg Inulin is a naturally occurring prebiotic fructan fiber derived from chicory root, belonging to the fructooligosaccharide class of carbohydrates that resist enzymatic digestion in the upper gastrointestinal tract and pass intact to the large intestine where they undergo selective fermentation by resident Lactobacillus and Bifidobacterium species. Fermentation of inulin by colonic microflora produces short-chain fatty acids — primarily butyrate, propionate, and acetate — that lower luminal pH within the colon, significantly increasing the ionization and passive diffusion absorption of calcium across the colonic epithelium through a mechanism entirely independent from the active, VDR-mediated calcium absorption supported by Vitamin D3 in the small intestine. This dual-pathway calcium absorption support — combining Vitamin D3-mediated active transport in the small intestine with inulin-mediated passive colonic absorption — makes Vitamin K2 Plus a uniquely comprehensive formula for maximizing dietary calcium bioavailability alongside the downstream osteocalcin and MGP carboxylation activity of Menaquinone-7.
