What it is: Thermoset® is a vegetarian, stimulant-conscious weight management formula developed by DaVinci Labs, delivering a multi-mechanistic blend of seven ingredients — including a proprietary 375 mg blend of Green Tea extract (standardized to 105 mg EGCG), Theobroma cacao whole fruit extract, Hoodia gordonii, and Eleutherococcus senticosus — alongside Guarana Seed extract, Suntheanine® L-Theanine, Banaba leaf extract (standardized to corosolic acid), Black Pepper extract, and Chromium (as polynicotinate). Formulated to address the multiple overlapping physiological factors that challenge weight management — including appetite, GLP-1 hormone support, thermogenesis, cortisol-driven fat accumulation, blood sugar regulation, and stress-related eating — Thermoset® provides a comprehensive, non-extreme approach to metabolic support appropriate for practitioner-directed use in weight management and cardiometabolic protocols, including as a complement to GLP-1-based weight management programs.
How it works: Thermoset® supports weight management through four coordinated and complementary mechanisms targeting appetite regulation, thermogenesis, cortisol management, and blood sugar support. For GLP-1 and appetite support, Green Tea extract (EGCG), Theobroma cacao whole fruit extract, and Banaba leaf extract (corosolic acid) collectively support the secretion and activity of glucagon-like peptide-1 (GLP-1) — the intestinal satiety hormone that controls appetite signaling and maintains healthy postprandial blood glucose — while Hoodia gordonii acts centrally on hypothalamic glucose-sensing neurons to promote satiety and reduce appetite drive, and Chromium (as polynicotinate) supports insulin receptor sensitivity and healthy blood glucose management. For thermogenesis and fat oxidation, Green Tea EGCG inhibits catechol-O-methyltransferase (COMT) to prolong norepinephrine-mediated thermogenic signaling, while Guarana Seed extract contributes naturally occurring caffeine (4 mg per capsule) and xanthine alkaloids that promote fat mobilization and metabolic rate. Theobroma cacao whole fruit extract provides theobromine alongside flavanols that support endothelial function and metabolic activity. Black Pepper (Piper nigrum) seed extract contributes piperine, which enhances the bioavailability of the formula's active botanical compounds while independently supporting thermogenesis through transient receptor potential vanilloid (TRPV1) channel activation. For cortisol and stress management, Eleutherococcus senticosus (Siberian Eleuthero) root provides adaptogenic support for HPA axis regulation and cortisol modulation, while Suntheanine® L-Theanine (25 mg) — the patented, pharmaceutical-grade L-theanine from Taiyo International — promotes alpha-wave brain activity and supports GABAergic calm without sedation, collectively attenuating the cortisol-driven appetite dysregulation and abdominal fat accumulation associated with chronic stress.
When to use it: Thermoset® is appropriate for practitioner-directed use in adult clients engaged in weight management protocols where appetite control, GLP-1 support, thermogenic fat oxidation, cortisol management, and blood sugar regulation are simultaneous clinical objectives. It is particularly well-suited for clients who experience stress-related eating, cravings for refined carbohydrates, cortisol-driven abdominal fat accumulation, or sluggish metabolism, and for those participating in GLP-1-based weight management programs seeking a complementary nutritional adjunct. Three capsules taken 30 minutes before each meal provides pre-meal appetite suppression and blood glucose support at the time of highest clinical relevance. As this formula naturally contains caffeine from Guarana, it is contraindicated in caffeine-sensitive clients and should not be used by clients with high blood pressure, fibrocystic breast disease, or those taking MAOI, SSRI, or antihypertensive medications.
Serving Size: 1 Capsule
Servings Per Container: 90
Suggested Use: As a dietary supplement, take 1 capsule 3 times daily, 30 minutes before each meal, or as directed by your healthcare practitioner.
| Amount Per Serving | % Daily Value | |
| Chromium (as Cr Polynicotinate) | 50 mcg | 142% |
| Proprietary Blend: Green Tea (Camellia sinensis L.) Leaf Extract, Theobroma cacao Whole Fruit Extract, Hoodia gordonii (Aerial Stem), Eleutherococcus senticosus (Root) — yielding EGCG 105 mg, Theobromine 10 mg, Caffeine 1 mg | 375 mg | * |
| Guarana Seed Extract (yielding Caffeine 4 mg) | 100 mg | * |
| L-Theanine (Suntheanine® Brand) | 25 mg | * |
| Banaba (Lagerstroemia speciosa L.) Leaf Extract (yielding Corosolic Acid 0.2 mg) | 10 mg | * |
| Black Pepper (Piper nigrum) Seed Extract | 5 mg | * |
* Daily Value not established.
Other Ingredients: Hypromellose (capsule), microcrystalline cellulose, vegetarian leucine.
Caution: Do not take this product if pregnant, nursing, have fibrocystic breast disease, high blood pressure, or if taking MAOI or SSRI drugs or antihypertensive medications. This product naturally contains caffeine. Do not take if caffeine sensitive. Discontinue use 2 weeks prior to surgery. Keep out of reach of children. Store in a cool, dry place. Color may vary due to natural ingredient variation.
✓ Vegetarian
Key Ingredients
Proprietary Blend — 375 mg (yielding EGCG 105 mg, Theobromine 10 mg, Caffeine 1 mg) This four-ingredient proprietary blend anchors the formula's thermogenic, GLP-1 supportive, and adaptogenic activity through the synergistic combination of Green Tea (Camellia sinensis) leaf extract, Theobroma cacao whole fruit extract, Hoodia gordonii aerial stem, and Eleutherococcus senticosus root. Green Tea extract, standardized to yield 105 mg EGCG per capsule, inhibits catechol-O-methyltransferase (COMT) to prolong norepinephrine-mediated thermogenic signaling in adipose tissue, supports GLP-1 secretion from intestinal L-cells, and provides potent catechin-class antioxidant activity for cardiovascular and metabolic protection. Theobroma cacao whole fruit extract contributes theobromine — a methylxanthine with mild central nervous system stimulation, vasodilatory, and mood-enhancing properties — alongside flavanols that support endothelial nitric oxide production, energy metabolism, and GLP-1 activity. Hoodia gordonii acts centrally on hypothalamic glucose-sensing neurons via its active steroidal glycoside P57, promoting satiety signals that reduce appetite drive and caloric intake. Eleutherococcus senticosus root provides adaptogenic eleutherosides that support HPA axis regulation, cortisol modulation, and physical endurance — addressing the stress-driven component of weight gain and metabolic dysregulation.
Guarana Seed Extract — 100 mg (yielding 4 mg Caffeine) Guarana (Paullinia cupana) seed extract is a South American botanical delivering a naturally occurring xanthine alkaloid complex — predominantly caffeine alongside theophylline and theobromine — in a matrix that releases more slowly than isolated caffeine, providing sustained metabolic activation without the abrupt stimulant peak associated with anhydrous caffeine supplementation. At 4 mg of naturally occurring caffeine per capsule (12 mg per daily three-capsule serving), Guarana provides a moderate thermogenic contribution that promotes lipolysis through beta-adrenergic receptor stimulation and enhances fatty acid oxidation in skeletal muscle and adipose tissue, supporting the formula's overall fat-burning activity without excessive central nervous system stimulation. The xanthine complex in Guarana works synergistically with Green Tea EGCG's COMT inhibition to extend and amplify catecholamine-driven thermogenesis through complementary and sequential mechanisms within the adrenergic signaling pathway.
L-Theanine (Suntheanine® Brand) — 25 mg Suntheanine® is a patented, pharmaceutical-grade L-theanine produced by Taiyo International through a proprietary enzymatic fermentation process, included in this formula specifically to counterbalance the mild stimulant activity of the formula's naturally occurring caffeine content and to address the cortisol and stress-driven component of appetite dysregulation and weight gain. L-Theanine promotes alpha-wave brain activity — the neural oscillation pattern associated with relaxed, alert wakefulness — and supports GABAergic and serotonergic neurotransmitter balance, attenuating the anxiety, cortisol elevation, and stress-related eating behavior that frequently undermine weight management outcomes without producing sedation or impairing the thermogenic activity of the formula's other ingredients. The combination of caffeine from Guarana and L-Theanine from Suntheanine® within a single formula reflects the well-established caffeine-theanine synergy documented in cognitive performance research, providing focused energy and mental clarity alongside the formula's metabolic and appetite-regulatory mechanisms.
Chromium (as Chromium Polynicotinate) — 50 mcg Chromium polynicotinate is a niacin-bound form of chromium delivering 142% of the daily value per capsule in a bioavailable organic form recognized for superior cellular uptake compared to chromium picolinate and chromium chloride. Chromium is an essential cofactor in the activity of the glucose tolerance factor (GTF) complex, which potentiates insulin receptor tyrosine kinase activity and enhances intracellular insulin signaling efficiency — supporting healthy blood glucose management, reducing postprandial glucose excursions, and attenuating the carbohydrate cravings associated with blood sugar instability. At three capsules per day delivering 150 mcg total daily chromium, this formula supports the insulin sensitivity and glucose regulatory activity that underpins the formula's GLP-1 support and appetite management objectives, providing a mineral-level metabolic foundation for the botanical and thermogenic components of the Thermoset® formula.
