What it is: HepaticClear™ is a comprehensive, vegetarian eleven-ingredient hepatic detoxification and liver support formula developed by DaVinci Labs, delivering targeted nutritional cofactors across all six Phase II detoxification conjugation pathways alongside Phase I cytochrome P450 membrane support, antioxidant protection, and glutathione biosynthesis support. The formula features Milk Thistle (Silybum marianum) seed extract (standardized to 160 mg silymarin), N-Acetyl Cysteine, L-Methionine, L-Glycine, Alpha Lipoic Acid, Calcium D-Glucarate, DIM® (proprietary bioavailability-enhanced diindolylmethane), Choline, Inositol, Turmeric root powder, and Biotin — each selected for its specific and documented role in hepatic Phase I or Phase II detoxification biochemistry. Designed for practitioner-directed use in liver health, detoxification, hormonal clearance, and hepatoprotective protocols, HepaticClear™ provides a mechanistically comprehensive approach to supporting the full arc of hepatic toxin processing — from initial cytochrome P450 transformation through final conjugation and excretion.
How it works: HepaticClear™ supports hepatic detoxification through precisely targeted nutritional support across both phases of liver detoxification. Phase I detoxification — mediated by the cytochrome P450 (CYP450) enzyme family embedded in hepatocyte cell membranes — requires healthy membrane integrity as its structural foundation: Choline (80 mg, as choline bitartrate) and Inositol (25 mg) are essential phospholipid membrane components that maintain the structural integrity of hepatocyte cell membranes in which the CYP450 enzymes are anchored, while simultaneously supporting hepatic fat and cholesterol metabolism. Biotin (50 mcg) supports cell growth, fat metabolism, and cellular energy generation within the liver. DIM® (25 mg, proprietary bioavailability-enhanced diindolylmethane complex) supports both Phase I and Phase II detoxification activity and specifically promotes the detoxification and clearance of estrogen metabolites through CYP1A1/1A2 modulation. Phase II detoxification — involving six conjugation pathways that neutralize Phase I-transformed intermediates for urinary or biliary excretion — is addressed across all six pathways: Calcium D-Glucarate supports glucuronidation by providing glucuronic acid substrate and inhibiting beta-glucuronidase to ensure elimination of fungal toxins, steroid hormones, and environmental xenobiotics; L-Glycine (25 mg) supports amino acid conjugation — the pathway that combines glycine with and neutralizes various toxins for biliary excretion, particularly important in clients on low-protein diets with chronic toxin exposure; L-Methionine (100 mg) provides the methionine substrate for SAMe production and methylation — one of the most critical Phase II pathways governing hormonal and neurotransmitter detoxification — while contributing sulfur for glutathione and sulfation pathway support; N-Acetyl Cysteine (50 mg) directly replenishes glutathione as the rate-limiting cysteine precursor for the glutathione conjugation pathway — the liver's primary detoxification route for reactive electrophilic intermediates; and Alpha Lipoic Acid (20 mg) provides dual-soluble antioxidant support to recycle glutathione, vitamin C, and vitamin E from their oxidized forms, amplifying the antioxidant network protecting hepatocytes from oxidative damage generated during Phase I metabolism. Milk Thistle extract (200 mg, yielding 160 mg silymarin) provides hepatocellular membrane stabilization, direct silymarin-mediated antioxidant protection, and silybin-driven glutathione synthesis support and hepatocyte regeneration promotion. Turmeric root powder contributes curcuminoid antioxidants that protect liver cells from free radical damage and support gallbladder function for bile storage and release.
When to use it: HepaticClear™ is appropriate for practitioner-directed use in adult clients requiring comprehensive Phase I and Phase II hepatic detoxification support, hepatocellular protection, and liver health maintenance. It is particularly well-suited for integration into detoxification protocols, post-pharmaceutical or post-antibiotic liver recovery programs, hormonal clearance and estrogen metabolism support protocols, environmental toxic burden programs, mold exposure recovery, and foundational liver wellness support for clients with elevated hepatic oxidative stress or suboptimal Phase II conjugation capacity. Two capsules daily — one taken twice daily — provides sustained hepatic detoxification cofactor support throughout the day. This formula is contraindicated in pregnancy, nursing, and for clients planning to become pregnant.
Serving Size: 1 Capsule
Servings Per Container: 60
Suggested Use: As a dietary supplement, take 1 capsule twice daily, or as directed by your healthcare practitioner.
|
Ingredient |
Amount Per Serving |
% Daily Value |
|
Biotin |
50 mcg |
167% |
|
Choline (as Choline Bitartrate) |
80 mg |
15% |
|
Calcium (as Calcium D-Glucarate) |
6 mg |
<1% |
|
Milk Thistle (Silybum marianum) Seed Extract (yielding Silymarin 160 mg) |
200 mg |
* |
|
L-Methionine |
100 mg |
* |
|
Turmeric (Curcuma longa) Root Powder |
80 mg |
* |
|
N-Acetyl Cysteine |
50 mg |
* |
|
Inositol |
25 mg |
* |
|
L-Glycine |
25 mg |
* |
|
DIM® (a proprietary enhanced bioavailability complex of starch, diindolylmethane, Vitamin E as tocophersolan, phosphatidylcholine, silica) |
25 mg |
* |
|
Alpha Lipoic Acid |
20 mg |
* |
* Daily Value not established.
Other Ingredients: Hypromellose (capsule), microcrystalline cellulose, vegetarian leucine.
Caution: If pregnant, nursing, or planning to become pregnant, do not take this product. Keep out of reach of children. Store in a cool, dry place. Color may vary due to natural ingredient variation.
✓ Gluten Free ✓ Vegetarian ✓ Soy Free
Key Ingredients
Milk Thistle (Silybum marianum) Seed Extract — 200 mg (yielding 160 mg Silymarin) Silybum marianum seed extract, standardized to 80% silymarin — the flavonolignan complex comprising silybin, silydianin, silychristin, and isosilybin, with silybin recognized as the most hepatoprotective individual constituent — provides the formula's primary hepatocellular membrane stabilization, antioxidant, and regenerative support. Silymarin modifies the lipid composition and structural integrity of hepatocyte outer membranes, reducing permeability to hepatotoxic compounds, while simultaneously providing potent free radical scavenging protection against reactive intermediates generated during Phase I CYP450 biotransformation. Silybin specifically stimulates RNA polymerase I-dependent ribosomal RNA synthesis in hepatocytes, promoting hepatocellular protein synthesis and regeneration, and supports intrahepatic glutathione levels — providing the direct antioxidant substrate replenishment that protects liver cells from the oxidative burden inherent to high-throughput toxin processing.
N-Acetyl Cysteine — 50 mg N-Acetyl Cysteine is the most bioavailable oral precursor to L-cysteine — the rate-limiting amino acid for intracellular glutathione biosynthesis — directly replenishing hepatocellular glutathione stores depleted by chronic toxin processing and Phase I-generated reactive electrophilic intermediates. Within the Phase II glutathione conjugation pathway — the liver's primary detoxification route for reactive electrophiles, heavy metals, and xenobiotics — glutathione provides the nucleophilic thiol group that conjugates with and neutralizes toxic intermediates for safe biliary or urinary excretion, with adequate glutathione availability being the rate-limiting determinant of this pathway's capacity. NAC's role as the primary pharmaceutical antidote for acetaminophen overdose-induced hepatotoxicity — which operates through glutathione depletion — underscores its central clinical importance as a hepatoprotective glutathione precursor, making it an indispensable inclusion in any comprehensive Phase II detoxification support formula.
L-Methionine — 100 mg L-Methionine is an essential sulfur-containing amino acid that serves as the direct precursor to S-adenosylmethionine (SAMe) — the universal methyl donor for the methylation Phase II conjugation pathway — through which the liver methylates and neutralizes a broad spectrum of substrates including catecholamines, estrogens, histamine, and various xenobiotics for safe elimination. Beyond its methylation pathway role, L-Methionine's sulfur content is transsulfurated to cysteine through the transsulfuration pathway, contributing to glutathione biosynthesis and the sulfation Phase II conjugation pathway — providing dual detoxification pathway support through a single amino acid. L-Methionine additionally supports hepatic fat metabolism through its role as a lipotropic agent, promoting phosphatidylcholine synthesis and reducing the accumulation of hepatic fat associated with suboptimal methylation capacity.
DIM® (Diindolylmethane) — 25 mg DIM® (BioResponse LLC, US Patent #6,086,915) is a proprietary bioavailability-enhanced diindolylmethane complex — the primary bioactive indole metabolite of cruciferous vegetable indole-3-carbinol — that uniquely supports both Phase I and Phase II hepatic detoxification, making it the only ingredient in this formula with documented activity across both detoxification phases. In Phase I, DIM® modulates CYP1A1 and CYP1A2 enzyme induction to support the 2-hydroxylation of estrogens — redirecting estrogen metabolism toward the less estrogenic 2-hydroxyestrone pathway and away from the more biologically active 16α-hydroxyestrone. In Phase II, DIM® supports glucuronidation and sulfation of estrogen metabolites for elimination, providing comprehensive estrogen detoxification support from enzymatic processing through final conjugation and excretion — making this formula particularly relevant for clients in hormonal clearance and estrogen metabolism support protocols.
