What it is:
GlucoSynergy™ is a vegetarian, multi-ingredient glucose metabolism support formula developed by DaVinci Labs. The formula features seven clinically researched nutritional compounds, including Cinnulin PF® — a patented, water-soluble cinnamon bark extract — alongside botanical extracts standardized to active constituents, bioavailable trace minerals, and alpha-lipoic acid. Formulated for integration into practitioner-directed metabolic support protocols, GlucoSynergy™ provides a non-stimulant, evidence-informed approach to supporting healthy glucose homeostasis, insulin sensitivity, and cellular antioxidant defense in clients presenting with blood sugar management concerns or elevated cardiometabolic risk.
How it works:
GlucoSynergy™ operates through complementary, multi-pathway mechanisms central to glucose homeostasis and cellular energy metabolism. Cinnulin PF® (a patented, water-soluble Type-A polyphenol extract of Cinnamomum cassia bark) supports insulin receptor substrate phosphorylation and promotes GLUT4-mediated intracellular glucose uptake. Gymnema sylvestre leaf extract, standardized to gymnemic acids, helps attenuate intestinal glucose absorption via inhibition of intestinal sodium-glucose cotransporters and supports pancreatic beta-cell integrity, contributing to normal postprandial glucose regulation. Lagerstroemia speciosa L. (Banaba leaf), standardized to corosolic acid, facilitates cellular glucose transport through GLUT4 transporter activation, promoting peripheral glucose utilization. Bitter melon (Momordica charantia) extract, yielding the active constituent charantin, exhibits insulin-mimetic activity and helps maintain blood glucose levels already within the normal range. Vanadyl sulfate, an inorganic vanadium compound, has been shown in human studies to promote hepatic glucose production suppression and modest improvements in peripheral insulin-mediated glucose disposal. Chromium (as Chromemate® niacin-bound chromium polynicotinate) supports the function of the glucose tolerance factor (GTF) complex, enhancing insulin receptor sensitivity and downstream intracellular glucose metabolism. Alpha-lipoic acid, a potent mitochondrial antioxidant, helps neutralize reactive oxygen species generated during glucose metabolism, supports regeneration of endogenous antioxidants including glutathione and vitamins C and E, and plays a cofactor role in pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes central to cellular energy production.
When to use it:
GlucoSynergy™ is appropriate for use in clinical protocols targeting glycemic support, insulin sensitivity, and metabolic wellness in adult clients. It is particularly well-suited for practitioner-directed use in individuals seeking nutritional support for blood sugar levels already within the normal range, those with cardiometabolic risk factors, or clients following low-glycemic or weight management dietary programs. The flexible dosing schedule — one capsule with a meal, one to three times daily — allows for individualized titration based on clinical presentation and practitioner judgment. As with all botanical and trace-mineral glucose support formulas, use in clients concurrently taking glucose-lowering medications or insulin should be monitored with appropriate clinical oversight.
Serving Size: 1 Capsule
Servings Per Container: 60
Suggested Use: As a dietary supplement, take 1 capsule with a meal, 1–3 times daily, or as directed by your healthcare practitioner.
| Ingredient | Amount Per Serving | % Daily Value |
| Chromium (as Chromemate® Cr Polynicotinate) | 200 mcg | 571% |
|
Gymnema sylvestre Leaf Extract (yielding Gymnemic Acid 50 mg) |
200 mcg | † |
| Cinnulin PF® (Cinnamon Bark Extract) | 125 mg | † |
| Alpha-Lipoic Acid | 100 mg | † |
| Bitter Melon (Momordica charantia) Extract (yielding Charantin 0.4 mg) | 80 mg | † |
| Lagerstroemia speciosa L. (Banaba Leaf) Extract (yielding Corosolic Acid 0.5 mg) | 50 mg | † |
| Vanadyl Sulfate | 5 mg | † |
† Daily Value not established.
Other Ingredients: Hypromellose (capsule), microcrystalline cellulose, vegetarian leucine.
Caution: If pregnant or nursing, consult your healthcare practitioner before use. Discontinue use 2 weeks prior to surgery. Keep out of reach of children. Store in a cool, dry place. Color may vary due to natural ingredient variation.
✓ Vegetarian ✓ Gluten Free ✓ Dairy Free ✓ Soy Free ✓ Non-GMO
Key Ingredients
Cinnulin PF® (Cinnamon Bark Extract) — 125 mg A patented, water-soluble extract of Cinnamomum cassia bark (US Patent #7,504,118 & #8,003,141) concentrated in bioactive Type-A doubly-linked polyphenols. Unlike fat-soluble cinnamon compounds associated with hepatotoxicity risk, Cinnulin PF® is specifically processed to remove potentially harmful cinnamaldehyde and coumarin fractions, yielding a purer, safer extract. Supports insulin receptor substrate phosphorylation and promotes GLUT4-mediated intracellular glucose uptake, helping to maintain healthy glucose management and insulin utilization by cells.
Chromemate® Chromium Polynicotinate — 200 mcg A patented niacin-bound form of chromium recognized for superior bioavailability and cellular uptake compared to chromium picolinate and chromium chloride forms. Chromium is an essential trace mineral cofactor in the activity of the glucose tolerance factor (GTF) complex, which potentiates insulin receptor signaling and supports efficient intracellular glucose metabolism. Helps maintain blood sugar levels already within the normal range and promotes appropriate cellular insulin response.
Gymnema sylvestre Leaf Extract — 200 mg (yielding 50 mg Gymnemic Acids) Standardized to 25% gymnemic acids — the primary bioactive triterpenoid saponins responsible for this herb's clinically recognized activity. Gymnemic acids share structural similarity to glucose molecules and competitively inhibit intestinal glucose absorption at the brush border epithelium. Additionally, Gymnema sylvestre supports pancreatic beta-cell integrity and promotes normal insulin secretion, contributing to healthy postprandial glucose regulation and reduced carbohydrate craving signaling.
Alpha-Lipoic Acid — 100 mg A naturally occurring, mitochondria-centered dithiol antioxidant uniquely soluble in both aqueous and lipid environments, providing broad-spectrum free radical scavenging across cellular compartments. Functions as an essential cofactor in the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase enzyme complexes, directly supporting mitochondrial energy production from glucose substrates. Additionally supports the regeneration of endogenous antioxidants including glutathione, vitamin C, and vitamin E, helping to attenuate oxidative stress associated with glucose metabolism dysregulation.
Bitter Melon (Momordica charantia) Extract — 80 mg (yielding 0.4 mg Charantin) Standardized to charantin, a steroidal glycoside with documented insulin-mimetic activity. Bitter melon contains multiple bioactive constituents — including charantin, polypeptide-p, and vicine — that collectively support glucose uptake in peripheral tissues and help maintain blood glucose levels already within the normal range. Provides complementary insulin-sensitizing activity alongside the formula's botanical and mineral components, supporting a multi-targeted approach to healthy glucose homeostasis.
Lagerstroemia speciosa L. (Banaba Leaf) Extract — 50 mg (yielding 0.5 mg Corosolic Acid) Standardized to corosolic acid, the principal bioactive triterpenoid in Banaba leaf with well-characterized glucose transport-facilitating activity. Corosolic acid promotes GLUT4 transporter translocation to the cell surface, enhancing insulin-stimulated glucose uptake in muscle and adipose tissue. Additionally, Banaba leaf constituents have demonstrated inhibitory activity at the level of intestinal alpha-glucosidase, supporting attenuated postprandial glucose excursion.
Vanadyl Sulfate — 5 mg An inorganic vanadium salt representing one of the most studied forms of the trace element vanadium in the context of glucose metabolism. Vanadyl sulfate has demonstrated the ability to suppress excessive hepatic glucose production and promote modest improvements in peripheral, insulin-mediated glucose disposal in human clinical studies. Functions as an insulin-mimetic agent at the post-receptor level, supporting intracellular signaling cascades involved in glucose uptake independent of direct insulin receptor binding.
