What it is: Gluconic® DMG 500 mg is a chewable, gluten-free N,N-Dimethylglycine (DMG) tablet formula developed by DaVinci Labs, delivering 500 mg of pure DMG per cherry-flavored chewable tablet. DMG is a naturally occurring amino acid derivative found at the intersection of glycine metabolism and the one-carbon methylation cycle, functioning as an intermediary methyl donor in a wide range of biochemical processes critical to immune function, energy metabolism, cardiovascular health, hepatic detoxification, and neurological performance. DaVinci Labs' Gluconic® DMG is one of the longest-standing and most recognized DMG formulas in the practitioner-channel supplement market, with a decades-long clinical history supporting its use as a versatile adaptogenic nutritional compound across multiple practitioner disciplines.
How it works: Gluconic® DMG supports health across multiple physiological systems through its central role as a methyl-donor intermediate in the one-carbon metabolic cycle. As a precursor to betaine and a secondary methyl donor in the methylation cascade, DMG promotes the remethylation of homocysteine to methionine — helping to maintain healthy homocysteine levels within normal ranges and supporting cardiovascular and hepatic health through improved methylation capacity. Methylation-dependent detoxification in the liver relies on adequate methyl group availability for Phase II conjugation reactions, making DMG a functional hepatic detoxification cofactor that supports the liver's capacity to neutralize and clear environmental toxins and metabolic waste products. DMG supports immune function by helping to maintain the body's normal antibody production and keeping immune cell populations primed and responsive during periods of physiological stress. Within the central nervous system, DMG promotes healthy neurotransmitter synthesis and supports phosphocreatine production — the energy reservoir molecule that facilitates rapid ATP regeneration in neurons and muscle cells, supporting mental alertness, cognitive sharpness, and physical endurance. DMG's adaptogenic properties help the body cope with both physical and psychological stress, supporting sustained energy levels, reduced fatigue accumulation, and improved recovery following exercise or exertion. As a glycine derivative, DMG additionally contributes one-carbon units to purine synthesis and serine biosynthesis, supporting cellular proliferation and DNA methylation integrity.
When to use it: Gluconic® DMG 500 mg is appropriate for practitioner-directed use in adult clients requiring support for methylation capacity, immune resilience, cardiovascular homocysteine regulation, hepatic detoxification, cognitive alertness, and physical endurance. It is particularly well-suited for integration into protocols targeting fatigue, athletic performance, immune support, homocysteine management, and detoxification programs, as well as for clients experiencing high physiological or psychological stress loads, shift workers, and those with suboptimal methylation capacity. One chewable tablet once to twice daily, or as directed by a practitioner, provides flexible dosing for individualized clinical titration.
Serving Size: 1 Tablet
Servings Per Container: 60
Suggested Use: As a dietary supplement, take 1 chewable tablet once or twice daily, or as directed by your healthcare practitioner.
| Amount Per Serving | % Daily Value | |
| N,N-Dimethylglycine (DMG) | 500 mg | * |
* Daily Value not established. Percent Daily Values are based on a 2,000-calorie diet.
Other Ingredients: Xylitol, malic acid, natural cherry flavor, vegetable stearate, silicon dioxide, zeaxanthin.
Caution: If pregnant or nursing, consult your healthcare practitioner before taking this product. Keep out of reach of children. Store in a cool, dry place. Color may vary due to natural ingredient variation.
✓ Gluten Free
Key Ingredients
N,N-Dimethylglycine (DMG) — 500 mg N,N-Dimethylglycine is a naturally occurring amino acid derivative and intermediary metabolite situated at the convergence of glycine catabolism and the one-carbon methylation cycle, functioning as a secondary methyl donor that contributes methyl groups to the S-adenosylmethionine (SAMe)-dependent methylation cascade — a biochemical process governing homocysteine remethylation, neurotransmitter synthesis, DNA methylation, and Phase II hepatic detoxification conjugation reactions. DMG supports cardiovascular health by promoting the remethylation of homocysteine to methionine through betaine-homocysteine methyltransferase (BHMT), helping to maintain healthy homocysteine concentrations within normal ranges and protecting vascular endothelium from the oxidative and inflammatory burden associated with hyperhomocysteinemia. Its adaptogenic properties support immune cell preparedness and antibody production during physiological stress, while its role in phosphocreatine synthesis and ATP regeneration supports mental alertness, cognitive sharpness, physical endurance, and post-exercise muscle recovery — making DMG a uniquely versatile single-ingredient nutritional compound with clinically relevant activity across immune, neurological, cardiovascular, and metabolic domains simultaneously.
