What it is: Garcinia Cambogia with ChromeMate® is a stimulant-free, two-ingredient weight management formula developed by DaVinci Labs, delivering 500 mg of Citrin® brand Garcinia cambogia fruit rind extract — standardized to yield 250 mg of hydroxycitric acid (HCA) per capsule — alongside 100 mcg of ChromeMate® brand Chromium Polynicotinate. Citrin® is a registered trademark garcinia extract and ChromeMate® is a patented niacin-bound chromium ingredient from InterHealth N.I., both representing clinically validated, standardized ingredient forms with established identity and purity standards. Unlike stimulant-containing weight management products, this formula contains no ephedra, caffeine, or sympathomimetic agents — making it appropriate for a broader range of clients including those contraindicated for stimulants. Designed for practitioner-directed use in weight management, lean body composition, and blood sugar support protocols, Garcinia Cambogia with ChromeMate® provides a clean, evidence-informed botanical and mineral combination targeting two primary drivers of weight management challenge: fat synthesis inhibition and insulin sensitivity support.
How it works: Garcinia Cambogia with ChromeMate® supports weight management through two complementary and synergistic mechanisms operating across fat metabolism, appetite regulation, and glucose-insulin signaling. HCA (hydroxycitric acid), the primary bioactive compound in Garcinia cambogia fruit rind, functions as a competitive inhibitor of ATP-citrate lyase — the cytosolic enzyme responsible for converting excess carbohydrate-derived citrate into acetyl-CoA, the foundational carbon substrate for de novo lipogenesis (new fat synthesis) in the liver. By temporarily inhibiting ATP-citrate lyase, HCA reduces the conversion of dietary carbohydrates into stored fat, while simultaneously increasing the availability of liver glycogen — which suppresses appetite-stimulating signals to the hypothalamus and promotes satiety, helping to reduce caloric intake and food cravings. HCA may additionally support serotonin levels in the brain through its influence on tryptophan availability, contributing to mood balance and appetite control through serotonergic pathways. ChromeMate® Chromium Polynicotinate — a patented, niacin-bound form of chromium recognized for its superior bioavailability compared to chromium picolinate and chromium chloride — supports the activity of the glucose tolerance factor (GTF) complex that potentiates insulin receptor tyrosine kinase signaling, enhancing the efficiency of cellular glucose uptake and reducing the compensatory insulin secretion associated with insulin resistance. By supporting healthy blood glucose levels and insulin sensitivity, ChromeMate® addresses the metabolic underpinning of carbohydrate cravings and fat storage tendency — providing the glucose-regulatory complement that amplifies HCA's fat synthesis inhibition within a single capsule formula.
When to use it: Garcinia Cambogia with ChromeMate® is appropriate for practitioner-directed use in adult clients requiring stimulant-free support for weight management, appetite control, lean body composition, and blood glucose regulation already within normal ranges. It is particularly well-suited for clients who cannot tolerate stimulant-containing weight management products, those with carbohydrate-driven appetite challenges or blood sugar instability contributing to weight management difficulty, and clients seeking a clean, two-ingredient botanical and mineral formula as part of a comprehensive dietary and lifestyle weight management program. One capsule taken 30–60 minutes before each meal with a full glass of water supports pre-meal HCA bioavailability and appetite-regulatory timing relative to food intake, with up to three capsules daily providing the full clinical HCA and chromium dose.
Serving Size: 1 Capsule
Servings Per Container: 90
Suggested Use: As a dietary supplement, take 1 capsule 30–60 minutes before each meal with a full glass of water, or as directed by your healthcare practitioner.
|
Ingredient |
Amount Per Serving |
% Daily Value |
|
Chromium (as ChromeMate® Cr Polynicotinate) |
100 mcg |
286% |
|
Garcinia Cambogia Extract (Citrin® Brand) (yielding Hydroxycitric Acid 250 mg) |
500 mg |
* |
* Daily Value not established.
Other Ingredients: Hypromellose (capsule), microcrystalline cellulose, vegetarian leucine.
Caution: If pregnant or nursing, consult your healthcare practitioner before taking this product. Keep out of reach of children. Store in a cool, dry place. Color may vary due to natural ingredient variation.
✓ Gluten Free ✓ Vegetarian
Key Ingredients
Garcinia Cambogia Extract (Citrin® Brand) — 500 mg (yielding 250 mg Hydroxycitric Acid) Citrin® is a registered trademark Garcinia cambogia fruit rind extract standardized to 50% hydroxycitric acid (HCA) — the primary tricarboxylic acid compound responsible for the species' well-characterized fat synthesis inhibitory and appetite-regulatory activity. HCA functions as a competitive inhibitor of ATP-citrate lyase, the cytosolic enzyme that cleaves mitochondrially exported citrate into oxaloacetate and acetyl-CoA — the carbon substrate for de novo hepatic lipogenesis — effectively reducing the liver's capacity to convert excess dietary carbohydrates into stored triglycerides. The resulting accumulation of liver glycogen from reduced acetyl-CoA availability triggers hypothalamic satiety signaling that suppresses appetite and reduces food intake through glycostatic feedback mechanisms, while simultaneously reducing malonyl-CoA production — a metabolic intermediate that inhibits fatty acid oxidation — thereby creating a metabolic environment more favorable to fat mobilization than fat storage. At 250 mg of standardized HCA per capsule and up to 750 mg per three-capsule daily serving, Citrin® delivers a clinically relevant HCA dose within the range studied in human weight management trials, without stimulant activity, cardiovascular side effects, or tolerance development.
ChromeMate® Chromium Polynicotinate — 100 mcg ChromeMate® is a patented, niacin-bound chromium ingredient from InterHealth N.I. — delivering chromium as chromium polynicotinate, the most bioavailable and biologically active organic chromium form, with demonstrated superior cellular uptake and biological activity compared to chromium picolinate and chromium chloride forms. As an essential trace mineral cofactor for the glucose tolerance factor (GTF) complex, chromium potentiates insulin receptor tyrosine kinase activity and downstream intracellular insulin signaling, enhancing the efficiency of glucose uptake from the bloodstream into skeletal muscle, adipose, and hepatic cells — supporting healthy blood glucose levels already within normal ranges and reducing the compensatory hyperinsulinemia associated with insulin receptor insensitivity. At 100 mcg per capsule (286% DV) and up to 300 mcg per three-capsule daily serving, ChromeMate® provides a meaningful glucose tolerance factor-supporting chromium dose that complements HCA's fat synthesis inhibitory mechanism by addressing the insulin sensitivity and glucose regulatory dimension of carbohydrate-driven weight management challenges — creating a dual-mechanism, stimulant-free formula targeting both fat production and glucose metabolism simultaneously.
