What it is: Estro Benefits™ is a vegetarian, five-ingredient hormone balance and estrogen metabolism support formula developed by DaVinci Labs, combining DIM® (a proprietary bioavailability-enhanced diindolylmethane complex), Green Tea (Camellia sinensis) leaf extract (standardized to 175 mg EGCG), HMRlignan™ (a Norway Spruce (Picea abies) standardized lignan extract), trans-Resveratrol (from Polygonum cuspidatum root extract), Calcium D-Glucarate, Vitamin D3 (as cholecalciferol), and Vitamin E (as d-alpha tocopheryl succinate) within a single two-capsule daily serving. DIM® is a registered trademark of BioResponse LLC (US Patent #6,086,915) and HMRlignan™ is a trademark used under sublicense from Linnea S.A. — both representing clinically validated, standardized forms of their respective active compounds. Designed for practitioner-directed use in hormonal balance protocols for both men and women, Estro Benefits™ addresses estrogen metabolism, testosterone balance, breast and prostate tissue health, environmental toxin elimination, cellular health, and bone support through complementary botanical and nutritional mechanisms.
How it works: Estro Benefits™ supports hormonal health through four coordinated mechanisms targeting estrogen metabolism pathway direction, testosterone balance, detoxification, and cellular protective antioxidant defense. DIM® (100 mg) — a proprietary bioavailability-enhanced complex of diindolylmethane with Vitamin E tocophersolan and phosphatidylcholine — modulates hepatic cytochrome P450 enzyme activity to promote the 2-hydroxylation pathway of estrogen metabolism, shifting the estrogen metabolite ratio toward the more favorable 2-hydroxyestrone (2-OHE1) and away from the more estrogenically potent 16α-hydroxyestrone — a shift associated with improved hormonal balance, breast tissue health, and prostate health in both sexes. HMRlignan™ — a standardized 7-hydroxymatairesinol lignan extracted from Norway Spruce (Picea abies) knot — is converted by gut microbiota to enterolactone, a phytoestrogen that competitively modulates estrogen receptor activity and promotes favorable estrogen elimination pathways, working synergistically with DIM® to ensure used estrogen is eliminated through a health-promoting pathway. Green Tea extract (250 mg, yielding 175 mg EGCG) promotes healthy sex hormone binding globulin (SHBG) levels to reduce free testosterone conversion to DHT via 5-alpha reductase inhibition, supporting testosterone balance in both men and women, while simultaneously contributing to breast and prostate tissue health through EGCG's well-characterized activity on cellular proliferation signaling pathways. Trans-Resveratrol (50 mg, from Polygonum cuspidatum) provides complementary testosterone metabolism support through aromatase modulation, cellular antioxidant defense, and endothelial cardiovascular protection. Calcium D-Glucarate (delivering 50 mg Calcium) supports the glucuronidation detoxification pathway — a primary Phase II hepatic conjugation route for estrogen and environmental xenoestrogen elimination — by inhibiting beta-glucuronidase, the enzyme that cleaves glucuronide conjugates and allows toxins and used estrogen to be reabsorbed rather than eliminated. Vitamin D3 (1,000 IU) supports bone calcium absorption, healthy aromatase regulation, and cellular division signaling, while Vitamin E (33.5 mg, as d-alpha tocopheryl succinate) provides fat-soluble antioxidant support for cellular membrane protection in hormone-sensitive tissues.
When to use it: Estro Benefits™ is appropriate for practitioner-directed use in adult male and female clients requiring targeted nutritional support for estrogen metabolism optimization, hormonal balance, testosterone metabolism, breast and prostate tissue health, environmental toxin elimination, and cellular protective antioxidant defense. It is particularly well-suited for perimenopausal and postmenopausal women, men with hormonal balance concerns or elevated estrogen-to-testosterone ratios, clients with elevated environmental xenoestrogen burden, and those in protocols addressing breast or prostate tissue health through hormonal metabolite pathway optimization. Two capsules daily provides a balanced daily dose of the formula's hormonal and detoxification support matrix. This formula is strictly contraindicated in pregnancy, nursing, and in clients planning to become pregnant.
Serving Size: 2 Capsules
Servings Per Container: 30
Suggested Use: As a dietary supplement, take 2 capsules daily, or as directed by your healthcare practitioner.
| Amount Per Serving | % Daily Value | |
| Vitamin D3 (as Cholecalciferol) | 25 mcg (1,000 IU) | 125% |
| Vitamin E (as d-alpha Tocopheryl Succinate) | 33.5 mg | 223% |
| Calcium (as Calcium D-Glucarate) | 50 mg | 4% |
| DIM® (a proprietary enhanced bioavailability complex of starch, diindolylmethane, Vitamin E as tocophersolan, phosphatidylcholine, silica) | 100 mg | * |
| Green Tea (Camellia sinensis) Leaf Extract (yielding EGCG 175 mg) | 250 mg | * |
| HMRlignan™ (Norway Spruce [Picea abies] Standardized Lignan Extract) | 30 mg | * |
| Trans-Resveratrol (from Japanese Knotweed [Polygonum cuspidatum] Root Extract) | 50 mg | * |
* Daily Value not established.
Other Ingredients: Hypromellose (capsule), microcrystalline cellulose, silica, vegetarian leucine.
Caution: If pregnant, nursing, or planning to become pregnant, do not take this product. Keep out of reach of children. Store in a cool, dry place. Color may vary due to natural ingredient variation.
✓ Gluten Free ✓ Vegetarian ✓ Soy Free
Key Ingredients
DIM® (Diindolylmethane) — 100 mg DIM® is a registered trademark of BioResponse LLC (US Patent #6,086,915), delivering diindolylmethane — the primary bioactive indole metabolite of cruciferous vegetable indole-3-carbinol — within a proprietary enhanced-bioavailability complex of starch, Vitamin E as tocophersolan, phosphatidylcholine, and silica that substantially improves the oral absorption of this inherently lipophilic, poorly water-soluble compound. DIM® modulates hepatic cytochrome P450 1A1 and 1A2 enzyme activity to promote the 2-hydroxylation pathway of estrogen metabolism — shifting the critical estrogen metabolite ratio toward the more favorable 2-hydroxyestrone (2-OHE1) and away from the more biologically potent 16α-hydroxyestrone — a shift with established clinical relevance for breast tissue health, prostate health, and overall hormonal balance in both male and female clients. At 100 mg per serving, DIM® delivers a clinically meaningful dose to support favorable estrogen metabolite balance, cellular health and division signaling, lean body composition support through estrogen repartitioning, and healthy aromatase activity regulation.
HMRlignan™ (Norway Spruce Picea abies Standardized Lignan Extract) — 30 mg HMRlignan™ is a trademark ingredient used under sublicense from Linnea S.A., providing 7-hydroxymatairesinol (7-HMR) — a plant lignan extracted from the knot wood of Norway Spruce (Picea abies) and among the richest known natural sources of this secoisolariciresinol-class lignan compound. Following oral ingestion, 7-HMR is efficiently converted by gut microbiota to enterolactone — a mammalian phytoestrogen with established selective estrogen receptor modulator (SERM)-like activity that competitively modulates estrogen receptor binding, promotes favorable estrogen elimination pathways, and works synergistically with DIM® to ensure that metabolized estrogen is directed through glucuronidation-dependent elimination channels rather than recirculated through enterohepatic recycling. HMRlignan™ provides a novel and complementary estrogen metabolism optimization mechanism to DIM® — addressing the elimination phase of estrogen clearance while DIM® addresses the metabolic pathway direction phase — creating a comprehensive two-stage estrogen metabolism support approach within a single formula.
Green Tea (Camellia sinensis) Leaf Extract — 250 mg (yielding 175 mg EGCG) Green Tea leaf extract, standardized to yield 175 mg of EGCG (epigallocatechin-3-gallate) per serving, provides the most concentrated polyphenol catechin fraction from Camellia sinensis — the primary bioactive compound responsible for green tea's well-characterized hormonal balance, antioxidant, and cellular health activities. EGCG has been identified as the most pharmacologically active agent in green tea with respect to hormonal metabolism — promoting higher levels of sex hormone binding globulin (SHBG) to reduce the proportion of free testosterone available for DHT conversion via 5-alpha reductase, and supporting healthy aromatase regulation to maintain appropriate testosterone-to-estrogen balance in both sexes. EGCG's established activity at key signaling pathways governing cellular division — including EGFR, PI3K/Akt, and MAPK pathway modulation — supports healthy cell cycle regulation in hormone-sensitive breast and prostate tissue, providing cellular protective activity that complements the estrogen metabolite pathway optimization of DIM® and HMRlignan™.
Calcium D-Glucarate (as Calcium D-Glucarate delivering 50 mg Calcium) Calcium D-Glucarate is the calcium salt of D-glucaric acid — a naturally occurring compound present in many fruits and vegetables — that supports the glucuronidation detoxification pathway, one of the primary Phase II hepatic conjugation routes through which the liver packages estrogen, environmental xenoestrogens, and other lipophilic toxins for safe biliary elimination. Its primary mechanism involves inhibition of beta-glucuronidase — a bacterial and hepatic enzyme that cleaves glucuronide conjugates in the intestine and liver, allowing conjugated estrogen and toxins to be deconjugated and reabsorbed rather than excreted — effectively preserving the integrity of the glucuronidation elimination pathway and ensuring that metabolized estrogen and environmental substances complete their full excretion pathway. This beta-glucuronidase inhibitory activity positions Calcium D-Glucarate as the detoxification complement to DIM® and HMRlignan™'s metabolic pathway-directing activity, comprehensively supporting the full arc of estrogen processing from hepatic metabolism through final intestinal elimination.
Trans-Resveratrol — 50 mg (from Polygonum cuspidatum Root Extract) Trans-resveratrol — the biologically active stilbene polyphenol isomer from Japanese Knotweed root — provides complementary hormonal balance support through selective aromatase enzyme inhibition, reducing the conversion of androgens to estrogens in peripheral adipose and adrenal tissue and supporting healthy testosterone-to-estrogen ratios in both men and women. Its polyphenolic antioxidant activity and SIRT1 activation contribute to cardiovascular endothelial protection, healthy LDL oxidation balance, and cellular senescence pathway modulation through mechanisms that complement the formula's EGCG and Vitamin E antioxidant contributions. As a phytoestrogen with selective estrogen receptor beta (ERβ) affinity — the receptor subtype preferentially expressed in bone and the cardiovascular system — trans-resveratrol supports bone mineralization and cardiovascular endothelial health alongside its hormonal metabolism activity, providing multi-system benefit that extends the formula's clinical relevance beyond purely hormonal applications.
