What it is: ENZ-FLAME™ is a comprehensive, 14-ingredient joint comfort and musculoskeletal support drink mix developed by DaVinci Labs, combining Cetyl Myristoleate (CMO) Complex, a Proprietary Proteolytic Enzyme Blend, Curcumin C3 Complex®, Boswellia serrata extract, Ginger root extract, Quercetin, Rutin, Luteolin, Cayenne Pepper, and DMG HCl in a gluten-free, orange-flavored powder formula. Curcumin C3 Complex® is a patented and registered trademark of Sabinsa Corporation, standardized to deliver 190 mg curcuminoids per serving — one of the most clinically validated curcumin ingredients available. Designed for practitioner-directed use in joint health, sports recovery, and active lifestyle protocols, ENZ-FLAME™ addresses joint comfort through five simultaneous therapeutic mechanisms: cell membrane lubrication, prostaglandin and leukotriene modulation, proteolytic fibrin breakdown, free radical neutralization, and peripheral nerve comfort support — providing unparalleled multi-mechanistic joint and musculoskeletal support within a single daily serving.
How it works: ENZ-FLAME™ supports joint health, comfort, and mobility through five coordinated and overlapping therapeutic mechanisms. Cetyl Myristoleate (CMO) Complex (1,000 mg) — a naturally occurring group of cetylated fatty acid esters — supports the lubrication of cell membranes within joint tissue that break down under everyday physical wear, and modulates prostaglandin production to support joint comfort through lipid-mediated inflammatory balance. Boswellia serrata gum extract (200 mg, yielding 130 mg boswellic acids) selectively inhibits 5-lipoxygenase (5-LOX) to suppress leukotriene synthesis — a primary driver of joint inflammatory signaling — and works synergistically with Curcumin C3 Complex® (200 mg, yielding 190 mg curcuminoids), which inhibits NF-κB-mediated inflammatory gene expression and COX-2-driven prostaglandin synthesis, to provide complementary dual-pathway inflammatory modulation across both the leukotriene and prostaglandin arms of the arachidonic acid cascade. Ginger root extract (50 mg, yielding gingerols) provides additional prostaglandin management through modulation of arachidonic acid-metabolizing enzymes. The Proprietary Proteolytic Enzyme Blend (465 mg, comprising Pancreatin, Bromelain, Papain, Pepsin, and Protease) supports the breakdown of fibrin — an insoluble protein associated with fluid retention and tissue discomfort — promoting healthy blood flow, oxygen delivery, and nutrient distribution to joint and muscle tissue. The flavonoid antioxidant matrix of Quercetin (75 mg), Rutin (200 mg), and Luteolin from Perilla Leaf Extract (8 mg) provides plant-derived free radical scavenging across multiple polyphenol subclasses, protecting joint tissue from oxidative damage. Cayenne Pepper (5 mg, containing capsaicin) provides peripheral nerve comfort support through TRPV1 receptor-mediated desensitization, soothing sensitive joint tissue and helping modulate the neural signals transmitting discomfort. DMG HCl (250 mg) supports joint metabolism through immune system modulation, cellular energy enhancement, free radical defense, and methylation pathway support.
When to use it: ENZ-FLAME™ is appropriate for practitioner-directed use in adult clients requiring comprehensive joint comfort, lubrication, mobility, and recovery support following moderate to intense physical activity, occasional discomfort, or the cumulative joint stress of everyday life. It is particularly well-suited for integration into athletic recovery protocols, active lifestyle musculoskeletal programs, and joint comfort protocols for clients presenting with occasional neck, hip, or knee discomfort, limited range of motion, or post-exercise tissue stress. One scoop (9 g) mixed in 8–10 oz of water daily provides sustained multi-mechanistic joint support. This formula is contraindicated in clients who are pregnant, nursing, taking anticoagulant or antiplatelet medications, or have gallstones or gallbladder disease.
Serving Size: 9 g (Approximately 1 Scoop)
Servings Per Container: 30
Suggested Use: As a dietary supplement, mix 9 grams (approximately one scoop) in 8–10 oz of water and take daily, or as directed by your healthcare practitioner.
| Amount Per Serving | % Daily Value | |
| Calories | 30 | — |
| Total Carbohydrates | 8 g | 3%† |
| — Dietary Fiber | 3 g | 11%† |
| Calcium | 40 mg | 3%† |
| Cetyl Myristoleate (CMO) Complex | 1,000 mg | * |
| Proprietary Proteolytic Enzyme Blend (Pancreatin, Bromelain, Papain, Pepsin, Protease) | 465 mg | * |
| N,N-Dimethylglycine HCl (DMG) | 250 mg | * |
| Curcumin C3 Complex® (yielding Curcuminoids 190 mg) | 200 mg | * |
| Boswellia serrata Gum Extract (yielding Boswellic Acid 130 mg) | 200 mg | * |
| Rutin | 200 mg | * |
| Quercetin (as Quercetin Dihydrate) | 75 mg | * |
| Ginger (Zingiber officinale) Root Extract (yielding Gingerols 2.5 mg) | 50 mg | * |
| Luteolin (from Perilla Leaf Extract) | 8 mg | * |
| Cayenne (Capsicum annum) Pepper | 5 mg | * |
| Stevia Leaf Extract | 100 mg | * |
* Daily Value not established.
† Percent Daily Values are based on a 2,000-calorie diet.
Other Ingredients: Digestion resistant maltodextrin, orange powder, natural orange flavor, citric acid, tricalcium phosphate, silicon dioxide.
Caution: Do not take this product if pregnant, nursing, taking anticoagulants/antiplatelet medications, or if you have gallstones or gallbladder disease. Discontinue use 2 weeks prior to any elective surgery. Jar contains desiccant to reduce moisture and clumping — do not eat desiccant. Keep out of reach of children. Store in a cool, dry place.
✓ Gluten Free
Key Ingredients
Cetyl Myristoleate (CMO) Complex — 1,000 mg Cetyl Myristoleate Complex (CMO) is a naturally occurring group of cetylated fatty acid esters — primarily cetyl myristoleate, cetyl myristate, cetyl palmitoleate, and cetyl oleate — that support joint health through two complementary lipid-mediated mechanisms: cell membrane lubrication and prostaglandin modulation. CMO integrates into the phospholipid bilayers of joint tissue cell membranes, providing structural lubrication and flexibility restoration to membranes that have degraded from physical wear, repetitive loading, or inflammatory damage — supporting the cushioning and shock-absorbing properties of articular tissue at the cellular membrane level. Additionally, CMO influences the prostaglandin biosynthetic pathway through its fatty acid substrate activity, supporting healthy prostaglandin levels within joint tissue and providing immune-modulatory support for joint comfort that operates through a mechanism entirely distinct from the enzyme inhibitory pathways addressed by Boswellia and Curcumin elsewhere in this formula.
Curcumin C3 Complex® — 200 mg (yielding 190 mg Curcuminoids) Curcumin C3 Complex® is a patented and registered trademark ingredient of Sabinsa Corporation, standardized to deliver a minimum 95% total curcuminoids in the characteristic C3 ratio — curcumin, bisdemethoxycurcumin, and demethoxycurcumin — representing the most extensively clinically researched curcumin ingredient available and the form used in the majority of human curcumin clinical trials. Curcumin's primary joint comfort mechanism involves potent inhibition of NF-κB — the master transcription factor governing pro-inflammatory cytokine, COX-2, and iNOS gene expression — as well as direct modulation of prostaglandin and leukotriene synthesis through complementary pathway activity. Curcumin C3 Complex® works synergistically with Boswellia serrata extract within this formula — with curcumin addressing COX and NF-κB pathways while boswellic acids address the 5-LOX leukotriene pathway — providing broader inflammatory pathway modulation than either botanical achieves independently, and Boswellia additionally supports hepatic function synergistically with curcumin.
Proprietary Proteolytic Enzyme Blend — 465 mg This five-enzyme proteolytic blend — comprising Pancreatin, Bromelain, Papain, Pepsin, and Protease — delivers systemic proteolytic activity targeting fibrin — the insoluble structural protein scaffold associated with tissue fluid retention, post-exercise muscle discomfort, and impaired microcirculatory flow — supporting its regulated breakdown to promote healthy blood flow, oxygen delivery, and nutrient distribution to joint and muscle tissue under physical stress. Each enzyme within this blend contributes a distinct substrate specificity and optimal pH range, ensuring comprehensive proteolytic activity across the gastrointestinal tract and systemic compartments: Pancreatin provides broad-spectrum pancreatic enzyme activity; Bromelain (pineapple-derived) and Papain (papaya-derived) contribute plant-based cysteine protease activity with established musculoskeletal and sinus tissue support; Pepsin provides acidic gastric protease activity; and Protease provides alkaline-range protein substrate coverage. Taken between meals, the systemic absorption of proteolytic enzymes from this blend supports joint tissue recovery and healthy fibrin regulation beyond the digestive tract.
Ginger (Zingiber officinale) Root Extract — 50 mg (yielding 2.5 mg Gingerols) Ginger root extract, standardized to gingerols — the primary bioactive phenolic ketone compounds responsible for ginger's anti-inflammatory and analgesic activity — supports joint comfort through selective inhibition of the enzymes responsible for metabolizing arachidonic acid into prostaglandins and leukotrienes, including both COX and 5-LOX pathway modulation. Gingerols additionally inhibit the synthesis of substance P and other neuropeptide mediators of pain signaling in peripheral tissue, providing complementary nerve-level comfort support that extends the formula's activity beyond purely prostaglandin and leukotriene-mediated mechanisms. The complementary prostaglandin-modulating activity of Ginger alongside CMO, Boswellia, and Curcumin C3 Complex® within this formula creates a multi-botanical, multi-pathway approach to healthy prostaglandin balance that addresses joint comfort from four simultaneous and overlapping mechanistic angles.
