What it is: Cortisol Benefits™ is a targeted, four-ingredient adaptogenic and botanical stress response formula developed by DaVinci Labs, combining ETAS™ (a proprietary enzyme-treated Asparagus officinalis extract), Rhodiola rosea root extract (standardized to 3% rosavins and 1% salidrosides), Shoden® Ashwagandha (Withania somnifera) extract (standardized to ≥35% glycowithanolides), and Magnolia officinalis bark extract — all within a clean, minimal-excipient vegetarian capsule. Each ingredient is a clinically studied, standardized adaptogen or stress-response botanical specifically selected for its documented activity on the hypothalamic-pituitary-adrenal (HPA) axis, cortisol regulation, and stress-resilience pathways. Designed for practitioner-directed use in cortisol management, adrenal support, and stress protocols, Cortisol Benefits™ addresses the multi-dimensional presentation of chronic stress — including elevated cortisol, sleep disruption, cognitive impairment under stress, fatigue, and mood imbalance — without inducing sedation or drowsiness.
How it works: Cortisol Benefits™ supports healthy stress response and cortisol regulation through four complementary adaptogenic and neuroendocrine mechanisms targeting the HPA axis, autonomic nervous system, and stress receptor activity. ETAS™ — a proprietary enzyme-treated hot water extract of Asparagus officinalis stem, developed by Amino Up — has been shown in double-blind, placebo-controlled human research to support healthy cortisol levels, maintain cognitive performance under stress, promote restful sleep, and improve heart rate variability (HRV) — a validated autonomic biomarker directly correlated with HPA axis balance and stress resilience. Its primary mechanism involves upregulation of heat shock protein 70 (HSP70) expression, which supports cellular stress adaptation and suppresses the downstream cortisol cascade. Shoden® Ashwagandha (Withania somnifera), standardized to the highest commercially available glycowithanolide concentration (≥35%), supports HPA axis modulation by attenuating cortisol secretion from the adrenal cortex, reducing serum cortisol levels, and promoting GABA-mimetic calming activity in the central nervous system — with clinical evidence supporting improvements in sleep quality, stress perception, energy, and morning alertness. Rhodiola rosea root extract, standardized to 3% rosavins and 1% salidrosides — the primary bioactive compounds responsible for its adaptogenic activity — supports the stress response through inhibition of monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT), prolonging the activity of stress-response neurotransmitters including serotonin, dopamine, and norepinephrine, while simultaneously modulating cortisol-induced suppression of cognitive function and promoting physical and mental endurance under load. Magnolia officinalis bark extract provides honokiol and magnolol — two neolignans that bind to GABA-A receptors and cortisol receptors in the nervous system — promoting relaxation, reducing cortisol-driven anxiety, and supporting healthy sleep onset and depth without sedative side effects.
When to use it: Cortisol Benefits™ is appropriate for practitioner-directed use in adult clients presenting with elevated or dysregulated cortisol, chronic stress, HPA axis imbalance, adrenal fatigue, cognitive impairment under stress, sleep disturbance, low mood, irritability, or the "wired and tired" presentation characteristic of sustained sympathetic nervous system activation. It is particularly well-suited for clients with demanding occupational or personal stress loads, shift workers with altered sleep-wake cycles, and those transitioning from acute to chronic stress states where adrenal recovery and cortisol normalization are primary clinical objectives. The non-sedating formulation allows for daytime use without impairing alertness or focus. This formula is contraindicated in hypoglycemic or diabetic clients without appropriate clinical oversight and should be discontinued two weeks prior to surgery.
Serving Size: 2 Capsules
Servings Per Container: 30
Suggested Use: As a dietary supplement, take 2 capsules daily, or as directed by your healthcare practitioner.
| Amount Per Serving | % Daily Value | |
| ETAS™ (proprietary extract of Asparagus officinalis) | 200 mg | * |
| Rhodiola rosea Root Extract (std. to 3% rosavins and 1% salidrosides) | 150 mg | * |
| Shoden® Ashwagandha (Withania somnifera) Extract | 120 mg | * |
| Magnolia officinalis Bark Extract | 100 mg | * |
* Daily Value not established.
Other Ingredients: Hypromellose (capsule), microcrystalline cellulose, vegetarian leucine.
Caution: If hypoglycemic, diabetic, pregnant, or nursing, consult your healthcare practitioner before taking this product. Discontinue use 2 weeks prior to surgery. Keep out of reach of children. Store in a cool, dry place. Color may vary due to natural ingredient variation.
✓ Gluten Free ✓ Soy Free
Key Ingredients
ETAS™ (Proprietary Extract of Asparagus officinalis) — 200 mg ETAS™ is a patented, enzyme-treated hot water extract of Asparagus officinalis stem developed by Amino Up, standardized through a proprietary enzymatic hydrolysis process that concentrates the asparagus-derived heat shock protein-inducing compounds — primarily asparagus-derived proline-rich peptides and hydroxycinnamic acid derivatives — responsible for its unique stress-adaptive and cortisol-modulating mechanism. Its primary documented mechanism involves upregulation of heat shock protein 70 (HSP70) expression — a cellular stress adaptation protein that helps mitigate the downstream physiological consequences of HPA axis activation and supports cellular resilience during sustained stress. In double-blind, placebo-controlled human research, ETAS™ has demonstrated the ability to support healthy cortisol levels, maintain cognitive performance under stressful conditions, promote restful sleep quality, and support healthy heart rate variability (HRV) — a validated autonomic biomarker directly correlated with HPA axis balance — establishing it as a clinically distinctive and evidence-supported ingredient within the cortisol and stress-response supplement category.
Shoden® Ashwagandha (Withania somnifera) Extract — 120 mg Shoden® is a patented, highly concentrated ashwagandha root and leaf extract produced by Arjuna Natural Pvt. Ltd., standardized to ≥35% glycowithanolides — the highest standardization level commercially available and significantly exceeding the 2.5–5% glycowithanolide content of conventional ashwagandha extracts — enabling clinically meaningful withanolide delivery at a substantially lower absolute dose. Its primary adaptogenic mechanism involves modulation of the HPA axis through suppression of adrenocortical cortisol secretion, reduction of serum cortisol concentrations, and GABA-mimetic activity in the central nervous system that attenuates stress-induced neurological hyperarousal. Shoden® has been clinically validated in human trials for its ability to support reductions in perceived stress and anxiety, improve sleep quality and efficiency, enhance morning alertness, and support healthy energy levels — making it the highest-potency, most evidence-supported ashwagandha ingredient available within this formula's cortisol and stress management application.
Rhodiola rosea Root Extract — 150 mg (std. to 3% Rosavins / 1% Salidrosides) Rhodiola rosea is a Scandinavian and Siberian adaptogenic botanical standardized here to the dual-marker specification of 3% rosavins and 1% salidrosides — the pharmaceutical-grade standardization established by human clinical trials and recognized as the benchmark for clinically active Rhodiola extracts. Rosavins and salidrosides act synergistically to inhibit monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) enzymes, prolonging the synaptic availability of serotonin, dopamine, and norepinephrine — neurotransmitters whose activity is suppressed by chronic cortisol elevation — thereby supporting mood, cognitive function, and mental endurance under physiological and psychological stress. Rhodiola's adaptogenic activity additionally supports physical stamina and recovery by improving cellular oxygen utilization and reducing cortisol-driven muscle protein catabolism, providing a dual mental and physical stress-resilience benefit that complements the HPA axis-focused mechanisms of ETAS™ and Shoden® within this formula.
Magnolia officinalis Bark Extract — 100 mg Magnolia officinalis bark extract delivers honokiol and magnolol — two structurally related biphenyl neolignan compounds that represent the primary bioactive constituents responsible for the extract's well-characterized anxiolytic, cortisol-modulating, and sleep-promoting activity. Honokiol and magnolol bind to GABA-A receptors in the central nervous system with affinity comparable to benzodiazepine-class compounds, promoting neurological calm and relaxation without producing the sedation, dependence, or cognitive impairment associated with pharmaceutical GABAergic agents — a clinically important distinction for daytime stress management use. Additionally, Magnolia officinalis extract has been shown to support normal cortisol and adrenaline levels through its activity at stress hormone receptors in the hypothalamus, providing complementary HPA axis support that reinforces the cortisol-normalizing mechanisms of ETAS™, Shoden®, and Rhodiola throughout the formula.
