What it is: Berberine Force is a vegetarian, four-ingredient cardiometabolic and weight management formula developed by DaVinci Labs, delivering 500 mg of Berberine (as Berberine HCl), 50 mg of LeucoSelect® Phytosome (a patented grape seed extract/phosphatidylcholine complex from Indena SpA), 25 mg of R-Alpha Lipoic Acid, and 200 mcg DFE of Folate as L-Methyltetrahydrofolate Calcium (L-MTHF) in a single clean-label vegetarian capsule. LeucoSelect® Phytosome is a registered trademark of Indena SpA, Italy, manufactured as a phytosome complex that dramatically enhances the bioavailability of grape seed extract's OPC content. Designed for practitioner-directed use in weight management, glucose support, cardiovascular health, and GLP-1 support protocols — including as a complementary nutritional adjunct to GLP-1-based weight management programs — Berberine Force addresses the cardiometabolic cluster of blood sugar dysregulation, elevated homocysteine, lipid imbalance, gut microbiome disruption, and weight management challenge within a single, evidence-informed formula.
How it works: Berberine Force supports cardiometabolic health through four complementary and overlapping mechanisms targeting GLP-1 secretion, glucose and insulin regulation, cardiovascular protection, and antioxidant defense. Berberine HCl (500 mg) — the primary alkaloid bioactive from Berberis species with one of the most extensively studied botanical metabolic profiles in clinical literature — activates AMP-activated protein kinase (AMPK), the cellular energy sensor often described as a metabolic master switch, promoting glucose uptake in peripheral tissues, supporting mitochondrial biogenesis, and improving insulin receptor sensitivity through post-receptor signaling. Berberine additionally protects and promotes the L-cells in intestinal crypts responsible for GLP-1 secretion, directly increasing GLP-1 release into the digestive tract — supporting appetite regulation, healthy postprandial glucose response, and the satiety signaling that drives reduced caloric intake. Berberine modulates gut microbiome composition by selectively promoting beneficial bacterial strains while suppressing pathogenic overgrowth, contributing to a healthier gut microbial environment that supports improved glucose metabolism, GLP-1 production, and intestinal barrier integrity. Additionally, Berberine supports healthy homocysteine levels and cholesterol within normal ranges through its hepatic and cardiovascular metabolic activity. LeucoSelect® Phytosome — a grape seed extract/phosphatidylcholine complex with dramatically enhanced bioavailability — independently supports GLP-1 production even in the setting of a suboptimal diet, increases satiety signaling after meals, and contributes cardiovascular antioxidant protection through its OPC (oligomeric proanthocyanidin) content. R-Alpha Lipoic Acid (25 mg) — the biologically active enantiomer of alpha-lipoic acid — supports healthy blood pressure, promotes HDL cholesterol production, helps maintain blood glucose within normal ranges, and provides dual-soluble antioxidant defense against free radical damage to vascular and metabolic tissue. Folate as L-Methyltetrahydrofolate Calcium (200 mcg DFE) supports homocysteine remethylation alongside Berberine's homocysteine-modulating activity, providing the active-form folate cofactor for methionine synthase without requiring MTHFR enzyme conversion.
When to use it: Berberine Force is appropriate for practitioner-directed use in adult clients requiring comprehensive cardiometabolic support including weight management, GLP-1 support, blood glucose regulation, cardiovascular homocysteine management, lipid balance, and gut microbiome support. It is particularly well-suited for integration into weight management protocols — including as a complementary adjunct to GLP-1-based pharmaceutical programs — metabolic syndrome support, prediabetes and insulin resistance protocols, cardiovascular risk reduction programs, and gut health optimization. One capsule twice daily with food provides optimal berberine dosing relative to meals for peak GLP-1 and glucose regulatory activity. Practitioners should be aware that Berberine may reduce the effectiveness of cytochrome P450-metabolized drugs and should exercise appropriate clinical oversight in clients on relevant medications.
Serving Size: 1 Capsule
Servings Per Container: 60
Suggested Use: As a dietary supplement, take 1 capsule twice daily with food, or as directed by your healthcare practitioner.
| Amount Per Serving | % Daily Value | |
| Folate (as L-Methyltetrahydrofolate Calcium) | 200 mcg DFE | 50% |
| Berberine (as Berberine HCl) | 500 mg | * |
| LeucoSelect® Phytosome (Grape Seed [Vitis vinifera] Extract / Phosphatidylcholine Complex) | 50 mg | * |
| R-Alpha Lipoic Acid | 25 mg | * |
* Daily Value not established.
Other Ingredients: Hypromellose (capsule), microcrystalline cellulose, vegetarian leucine.
Contains: Soy.
Caution: Do not take this product if pregnant or nursing. If taking CYP450-metabolized drugs, consult your healthcare practitioner before taking this product as Berberine may reduce the effectiveness of these medications. Keep out of reach of children. Store in a cool, dry place. Color may vary due to natural ingredient variation.
✓ Vegetarian ✓ Gluten Free ✓ Non-GMO
Key Ingredients
Berberine (as Berberine HCl) — 500 mg Berberine HCl is the hydrochloride salt form of berberine — a naturally occurring isoquinoline alkaloid found in the roots and bark of Berberis aristata, Coptis chinensis, and related plants — representing one of the most clinically investigated botanical compounds for cardiometabolic support, with a substantial peer-reviewed human trial portfolio encompassing blood glucose regulation, lipid management, cardiovascular protection, gut microbiome modulation, and GLP-1 secretion support. Berberine's primary metabolic mechanism involves activation of AMP-activated protein kinase (AMPK) — the cellular energy-sensing master kinase that promotes glucose uptake in skeletal muscle and adipose tissue, supports mitochondrial biogenesis, and improves insulin receptor post-receptor signaling sensitivity — while simultaneously protecting and stimulating intestinal L-cells responsible for GLP-1 secretion, directly increasing the endogenous release of this appetite- and glucose-regulatory hormone into the gut lumen. Berberine's gut microbiome-modulating activity — selectively promoting beneficial Lactobacillus and Bifidobacterium populations while suppressing pathogenic bacterial overgrowth — supports the intestinal microbial environment that underpins GLP-1 production capacity, glucose metabolism efficiency, and intestinal barrier integrity, establishing berberine as a uniquely multi-mechanistic single ingredient capable of addressing the cardiometabolic cluster simultaneously.
LeucoSelect® Phytosome — 50 mg LeucoSelect® Phytosome is a patented, bioavailability-enhanced grape seed extract (Vitis vinifera) formulated as a phytosome complex by Indena SpA — molecularly binding the extract's oligomeric proanthocyanidins (OPCs) to phosphatidylcholine to create a lipid-compatible structure that dramatically improves gastrointestinal absorption compared to unformulated grape seed extract. Within the context of this formula, LeucoSelect® provides two clinically relevant activities: first, independent GLP-1 secretion support that operates even in the setting of a suboptimal diet — stimulating intestinal L-cell GLP-1 release to promote satiety and post-meal fullness independently of dietary composition; and second, cardiovascular antioxidant protection through its highly bioavailable OPC content, supporting endothelial integrity, LDL oxidation resistance, capillary vascular health, and healthy inflammatory balance in cardiometabolic tissue. The phytosome delivery technology ensures that the OPC content reaches systemic circulation at concentrations sufficient to provide these cardiometabolic benefits — a clinical distinction not achievable with standard grape seed extract at comparable doses.
R-Alpha Lipoic Acid — 25 mg R-Alpha Lipoic Acid is the biologically active, naturally occurring enantiomer of alpha-lipoic acid — the form preferentially produced endogenously and utilized in mitochondrial enzyme complexes — offering superior antioxidant activity and metabolic cofactor efficacy compared to the racemic DL-ALA mixture in most standard formulations. Within this cardiometabolic formula, R-ALA supports healthy blood pressure regulation through its activity on vascular endothelial nitric oxide synthase, promotes HDL cholesterol production through its influence on reverse cholesterol transport pathways, helps maintain blood glucose within normal ranges through GLUT4 transporter upregulation and insulin receptor sensitization in peripheral tissue, and provides dual-soluble (both aqueous and lipid) free radical scavenging protection across the vascular and metabolic cellular compartments most vulnerable to oxidative damage in cardiometabolic dysfunction. Its glutathione-regenerating activity further amplifies the formula's overall antioxidant network alongside the OPC antioxidant content of LeucoSelect® Phytosome.
Folate (as L-Methyltetrahydrofolate Calcium) — 200 mcg DFE L-Methyltetrahydrofolate Calcium (L-MTHF) is the calcium salt of the predominant active form of folate in human plasma — delivered here in its immediately utilizable coenzyme form that bypasses the MTHFR enzyme conversion step required by standard folic acid, ensuring reliable folate activity independent of individual enzymatic conversion capacity or MTHFR polymorphism status. Within the cardiometabolic context of this formula, L-MTHF serves as the direct methyl donor for homocysteine remethylation via methionine synthase — working in parallel with Berberine's homocysteine-modulating activity to help maintain healthy homocysteine levels within the normal cardiovascular risk range, since elevated homocysteine is an independent cardiovascular risk factor associated with endothelial damage, thrombotic tendency, and vascular inflammation. L-MTHF additionally supports cognitive function, digestive comfort, and may contribute to insulin sensitivity and blood sugar balance through its methyl group donation to the one-carbon metabolic cycle governing neurotransmitter synthesis, DNA methylation, and cellular energy metabolism.
