What it is: Auto Immune 1™ is a six-ingredient botanical formula from Panaxea International supporting immune regulation, Th1/Th2 cytokine rebalancing, IL-10 promotion, and chronic inflammatory burden reduction. The formula has no known contraindications, making it well-suited for complex multi-medication clinical presentations. Manufactured to Australian Pharmaceutical GMP standards for exclusive practitioner-directed use.
How it works: Salvia miltiorrhiza (Tanshinone II-A) suppresses IL-12 production in activated macrophages and IFN-γ in primed lymphocytes — directly targeting the Th1 polarization signal at the transcriptional level. Trichosanthes root (Trichosanthin) promotes IL-10 output and suppresses TNF-α and IFN-γ, supporting T-regulatory cell activity characteristically deficient in autoimmune conditions. Caesalpinia sappan (Brazilin) inhibits NF-κB nuclear translocation and suppresses T-cell proliferation and pro-inflammatory cytokine production. Sedum acre contributes the formula's highest botanical dose with broad anti-inflammatory, antioxidant, and lymphatic circulatory support. Cuscuta racemosa flavones provide immunomodulatory and adrenal-supportive activity. Portulaca oleracea supports hepatoprotection and systemic inflammatory burden reduction.
When to use it: Indicated for adults with autoimmune conditions, chronic inflammatory disease, or Th1-dominant immune dysregulation. Two to three capsules two to three times daily, titrated to response. No known contraindications or drug interactions — suitable for use alongside concurrent medications under appropriate clinical oversight.
Serving Size: 2 Capsules
Servings Per Container: 30
Suggested Use: As a dietary supplement, take 2 capsules twice daily with food, or as prescribed by your healthcare practitioner.
|
Ingredient |
Amount Per Serving |
% Daily Value |
|
Caesalpinia (Caesalpinia sappan) Stem Heartwood Extract (Su Mu) |
128.34 mg |
† |
|
Salvia (Salvia miltiorrhiza) Root Extract (Dan Shen / Tanshinone IIA) |
68.32 mg |
† |
|
Portulaca (Portulaca oleracea) Flower & Leaf Extract (Ma Chi Xian) |
68.34 mg |
† |
|
Sedum (Sedum acre) Flower & Leaf Extract (Chui Pen Cao) |
384.32 mg |
† |
|
Trichosanthes (Trichosanthes kirilowii) Root Extract (Tian Hua Fen / Trichosanthin) |
188.34 mg |
† |
|
Cuscuta (Cuscuta racemosa) Seed Extract (Tu Si Zi / Total Flavones) |
198.34 mg |
† |
† Daily Value not established.
Other Ingredients: Vegetable cellulose (hypromellose), vegetable stearic acid, microcrystalline cellulose, vegetable magnesium stearate.
Does Not Contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts.
Caution: If pregnant or nursing, consult your healthcare practitioner before use. Do not use if you have known hypersensitivity to any of the ingredients. Do not use if tamper-evident seal is broken or missing. Keep out of reach of children. Store in a cool, dry place (<25°C) away from sunlight.
✓ Vegetarian ✓ Gluten Free ✓ Dairy Free ✓ Soy Free ✓ Egg Free ✓ Nut Free ✓ Australian Pharmaceutical GMP Manufactured
Key Ingredients
Salvia miltiorrhiza (Dan Shen root extract — Tanshinone II-A) — 68.32 mg Salvia miltiorrhiza is standardized to Tanshinone II-A — an abietane diterpene quinone with the most specifically Th1-targeted immunomodulatory activity in this formula. Published research demonstrates dose-dependent suppression of IL-12 production in LPS-activated macrophages and IFN-γ in KLH-primed lymphocytes, with Tanshinone II-A potently inhibiting IL-12 p40 gene promoter activation at the transcriptional level. It provides the formula's most precise Th1 cytokine-targeting mechanism alongside Trichosanthin's IL-10 promoting activity.
Trichosanthes kirilowii (Tian Hua Fen root extract — Trichosanthin) — 188.34 mg Trichosanthes kirilowii root delivers Trichosanthin and type I ribosome-inactivating proteins with documented immunomodulatory, IL-10 promoting, and Th1 cytokine-suppressive activity. Trichosanthin selectively modulates macrophage and T-cell activation states — promoting IL-10 output while suppressing IFN-γ and TNF-α, and supporting T-regulatory cell activity characteristically deficient in autoimmune conditions. It provides the formula's primary IL-10 promoting mechanism, directly pairing with Tanshinone II-A's IL-12 suppressive activity.
Caesalpinia sappan (Su Mu stem heartwood extract — Brazilin) — 128.34 mg Caesalpinia sappan heartwood delivers Brazilin and related homoisoflavonoids with documented NF-κB inhibitory, T-cell suppressive, and pro-inflammatory cytokine-reducing activity. Brazilin suppresses T-cell proliferation, inhibits TNF-α and IL-6 production, and blocks NF-κB nuclear translocation — targeting the central molecular driver of chronic inflammatory gene expression in autoimmune tissue damage. It provides the formula's primary NF-κB-targeted mechanism, complementing the cytokine-specific activities of Tanshinone II-A and Trichosanthin.
Cuscuta racemosa (Dodder seed extract — total flavones) — 198.34 mg Cuscuta racemosa seed is standardized to total flavones — including kaempferol glycosides and astragalin — with immunomodulatory, antioxidant, and adrenal-tonic activity. These flavones modulate T-lymphocyte proliferation, support adrenal cortex function and cortisol homeostasis, and activate Nrf2 antioxidant pathways to reduce the oxidative amplification of inflammatory tissue damage. At 198.34 mg it is the formula's second highest-dose ingredient, providing broad-spectrum flavonoid immunomodulatory and adrenal-supportive coverage.
Sedum acre (Stonecrop flower & leaf extract) — 384.32 mg Sedum acre is the formula's highest-dose ingredient, delivering alkaloids, flavonoids, and phenolic compounds with anti-inflammatory, antioxidant, and lymphatic circulatory support activity. Its constituents suppress inflammatory mediator production and support blood and lymph node microcirculation — directly addressing the vascular and lymphatic impairment that compromises immune cell trafficking and inflammatory resolution in autoimmune conditions. It provides the formula's broadest-spectrum anti-inflammatory volume and primary circulatory support activity.
