In the highly competitive world of nutritional supplements, few companies embody the ideals of clinical precision, integrity, and innovation as well as TruGen3. Founded in 2016 by L. Douglas Lioon—former CEO of Douglas Laboratories—and his family, TruGen3 represents the culmination of three generations of excellence in the nutraceutical field.
The name, short for “3 Generations of Truth,” is no coincidence: it reflects the company’s commitment to scientific integrity, patient-focused results, and delivering truth in nutrition across generations continuing with his sons, S. Michael and L. Douglas Lioon Jr.
Today, TruGen3 continues to build a sterling reputation as a trusted provider of clinically formulated, doctor-designed, and evidence-backed supplements, available exclusively to healthcare professionals.
Doctor-Formulated, Science-Driven Innovation
Unlike mass-market supplement brands, TruGen3’s formulations are physician-designed and scientifically validated. Each product begins with a foundation of clinical evidence, patient needs, and real-world healthcare practitioner feedback.
Every step of the formulation process—from ingredient selection to delivery technology—is guided by a singular principle: Formulate supplements that truly move the needle for patient outcomes.
TruGen3’s development process incorporates:
Review of published clinical trials on individual ingredients
- Ongoing collaboration with leading functional and integrative medicine physicians (Chris Meletis, N.D.)
- Prioritization of therapeutic dosing based on scientific evidence rather than marketing trends
- Commitment to "clean label" standards, eliminating unnecessary fillers, allergens, and additives wherever possible
Moreover, TruGen3’s unwavering focus on condition-specific support (e.g., inflammation modulation, cognitive function, healthy sleep, metabolic wellness) ensures that each product addresses key health needs with precision and potency.
1. Premium, Branded Ingredients for Maximum Bioavailability
In a crowded market filled with generic raw materials, TruGen3 distinguishes itself by using branded, clinically studied ingredients that offer superior quality and proven results.
One of TruGen3’s standout features is the use of VESIsorb®, a patented naturally self-assembling colloidal delivery system.
This technology dramatically enhances the absorption and bioavailability of fat-soluble nutrients such as cannabinoids, omega-3s, curcumin, and CoQ10.
Key Benefits of VESIsorb®:
- Increases solubility of poorly absorbed ingredients
- Provides consistent plasma concentrations
- Improves therapeutic effectiveness at lower doses
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Studies showing enhanced absorption of VESIsorb®
- CoQ10/VESIsorb® Study
- CBD/VESIsorb® Study
Branded Ingredient Examples:
- Cholesstrinol™ HP
- PMF-source® citrus flavones
- Tocosource® palm tocotrienols
- Kaneka-QH™-reduced form of coenzyme Q10
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OmegaChoice® Purified fish Oil -wild-caught Peruvian anchovies from the South Pacific
2. Formulation Philosophy: The TruGen3 Difference
At its core, TruGen3 is guided by a formulation philosophy built on five key pillars:
- Scientific Integrity
- Bioavailability: Patented delivery systems and enhanced absorption strategies ensure that active ingredients are utilized effectively by the body.
- Only ingredients supported by robust, peer-reviewed research make it into TruGen3 formulations Clinical Relevance: Every product is formulated with input from practicing clinicians to address real-world patient needs.
- Purity and Transparency: Raw materials are meticulously sourced and rigorously tested for identity, potency, and contaminants.
- Targeted Innovation: Rather than flooding the market with hundreds of products, TruGen3 selectively offers formulations that demonstrate unique value and superior performance.
This approach ensures that TruGen3 supplements are not just products, but integral tools that empower healthcare providers to improve patient outcomes.
3. Commitment to Healthcare Professionals
From its inception, TruGen3 has committed to serving healthcare professionals exclusively. This practitioner-first approach means:
- Providing technical documentation and clinical trial summaries for every product
- Offering practitioner education and clinical integration support
- Creating patient-friendly educational materials to enhance compliance and engagement
TruGen3 also collaborates closely with functional medicine and integrative health communities, offering webinars, live events, and case-study collaborations to advance the field of nutritional medicine.
Product Highlights
VESInol-QH™: Enhanced Absorption of Ubiquinol and Vitamin E
VESInol-QH™ is a specialized formulation delivering Kaneka-QH™ubiquinol - the reduced and active antioxidant form of coenzyme Q10 (CoQ10), alongside delta- and gamma-tocotrienols, advanced members of the vitamin E family with potent antioxidant and cardiovascular benefits. This product utilizes VESIsorb® Key Features:
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VESIsorb® technology enables superior absorption and bioavailability compared to standard CoQ10 products.
- CoQ10/VESIsorb® Study
- Contains Kaneka-QH™ubiquinol, the body’s preferred form of CoQ10, essential for mitochondrial energy production and cardiac health.
- Includes tocotrienols to further support healthy lipid metabolism, oxidative balance, and cellular function.
- Clinically suitable for patients with cardiovascular disease, chronic fatigue, or statin-induced CoQ10 depletion.
TG3 Heart Support™: Comprehensive Cardiovascular Nutritional Therapy
TG3 Heart Support™ is a multi-ingredient formula designed to provide foundational and targeted support for cardiovascular function, blood pressure modulation, and vascular integrity. It combines key nutrients and botanicals—each selected based on evidence for synergistic heart health benefits.
Key Features:
- Contains grape seed extract and green tea polyphenols, both rich in antioxidants that help protect endothelial function and reduce oxidative stress.
- Includes magnesium and potassium, essential minerals for healthy blood pressure and cardiac rhythm.
- Features L-citrulline to promote nitric oxide production and vascular relaxation.
- Supports arterial compliance, endothelial function, and circulatory health.
TG3 Heart Support is suited for integrative approaches to managing hypertension, atherosclerosis, and vascular inflammation, particularly when paired with lifestyle and dietary interventions.
Qmega-TG3™: Ultra-Pure Omega-3 Triglyceride Form
Qmega-TG3™ delivers highly concentrated EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) in their re-esterified triglyceride (rTG) form, which offers superior absorption and tolerability compared to ethyl ester forms. Each softgel is third-party tested for purity, potency, and oxidative stability.
Key Features:
- Re-esterified triglyceride form offers up to 70% greater absorption than ethyl ester omega-3s.
- Sourced from sustainably harvested cold-water fish - wild-caught Peruvian anchovies from the South Pacific
- Molecularly distilled for purity and toxin-free assurance.
- Provides clinically relevant doses of EPA and DHA, supporting lipid balance, inflammatory control, cognitive function, and cardiac health.
- Ideal for use in patients with dyslipidemia, inflammatory conditions, or elevated cardiovascular risk.
Qmega-TG3 exemplifies TruGen3’s dedication to clean-label, high-potency fish oil therapy supported by clinical evidence and advanced delivery form.
Together, these three products represent TruGen3’s formulation ethos: combining the highest quality ingredients, advanced absorption systems, and condition-specific applications to provide healthcare practitioners with tools that produce measurable results in cardiovascular and metabolic health.
Conclusion: Building the Future of Nutraceutical Truth
TruGen3 is not just another supplement company—it is the embodiment of a philosophy that prizes truth, science, and patient-centric innovation above all else.
By focusing on doctor-formulated, evidence-based supplements enhanced with the best branded ingredients and advanced delivery technologies, TruGen3 has earned its place as a leading name among healthcare professionals seeking to optimize patient health outcomes.
As the world of integrative and functional medicine continues to grow, TruGen3 remains steadfast in its mission to deliver clinical truth for a new generation—one practitioner, one patient, and one success story at a time.