TELOMERES are the DNA “cap” at the end of each chromosome that appears to have no genetic function but are critical for the protection of the chromosome and healthy cell function. Each time a cell divides the telomere becomes progressively shorter. Eventually, the telomere becomes too short and the cell can no longer divide. This aging cell either dies or becomes dysfunctional and can negatively impact the surrounding cells. Growing evidence suggests that telomere shortening can inhibit stem cell function, cellular regeneration, and organ maintenance eventually leading to overall aging of the body. Protecting and preserving telomeres has become an integral part of extending the life-span and longevity medicine. Physiological and cellular stress has been shown to increase telomere shortening and may explain why those under stress frequently age faster than those who are not. There are several nutrients that can help preserve telomere length and decrease cellular aging. RESVERATROL is a potent antioxidant found in red wine and has been shown to increase the life span and physical endurance in mammals. Resveratrol may enhance health and longevity via several mechanisms. One mechanism is by promoting the activation of sirtuins, a class of histone deacetylase enzymes (HDACs) involved in cell death and life-span regulation. Resveratrol has also been shown to regulate telomerase activity, thus protecting telomeres from damage. Until the more recent discovery of resveratrol’s life extending benefits, practicing a calorie restriction diet while maintaining good nutritional status was the only scientifically supported practice for extending the life span. The genetic pathways influenced by resveratrol are similar to those affected by a calorie restricted diet. For example, they both are associated with the long term activation of AMP-activated kinase (AMPK). Increased AMPK activity appears to lengthen lifespan by promoting insulin sensitivity. ASTRAGALUS is considered to be one of the most promising telomere anti-aging compounds after Resveratrol and Oligomeric Proanthocyanidins. Some studies indicate that this extract may have telomere protective properties. Astragalus is also known to support the immune system. Astragalus contains Astragolsides that have shown promise. The rare Astragoloside IV molecule, otherwise known as TA-65 may have telomere lengthening properties thus promoting enhanced cellular health, cellular regenerative functions and cellular longevity.
As a dietary supplement, take 3 capsules per day, in divided doses, between meals, or as directed by a healthcare professional.
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